Perspectives on human genetic variation from the HapMap project
The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibr...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797093831810744320 |
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| author | McVean, G Spencer, C Chaix, R |
| author_facet | McVean, G Spencer, C Chaix, R |
| author_sort | McVean, G |
| collection | OXFORD |
| description | The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it. © 2005 McVean et al. |
| first_indexed | 2024-03-07T04:05:51Z |
| format | Journal article |
| id | oxford-uuid:c61dd787-432a-45af-9f4b-71d5ecafd862 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:05:51Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:c61dd787-432a-45af-9f4b-71d5ecafd8622022-03-27T06:35:55ZPerspectives on human genetic variation from the HapMap projectJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c61dd787-432a-45af-9f4b-71d5ecafd862EnglishSymplectic Elements at Oxford2005McVean, GSpencer, CChaix, RThe completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it. © 2005 McVean et al. |
| spellingShingle | McVean, G Spencer, C Chaix, R Perspectives on human genetic variation from the HapMap project |
| title | Perspectives on human genetic variation from the HapMap project |
| title_full | Perspectives on human genetic variation from the HapMap project |
| title_fullStr | Perspectives on human genetic variation from the HapMap project |
| title_full_unstemmed | Perspectives on human genetic variation from the HapMap project |
| title_short | Perspectives on human genetic variation from the HapMap project |
| title_sort | perspectives on human genetic variation from the hapmap project |
| work_keys_str_mv | AT mcveang perspectivesonhumangeneticvariationfromthehapmapproject AT spencerc perspectivesonhumangeneticvariationfromthehapmapproject AT chaixr perspectivesonhumangeneticvariationfromthehapmapproject |