Genomic epidemiology reveals multiple introductions of Zika virus into the United States

Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the...

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Main Authors: Grubaugh, N, Ladner, J, Kraemer, M, Dudas, G, Tan, A, Gangavarapu, K, Wiley, M, White, S, Thézé, J, Magnani, D, Prieto, K, Reyes, D, Bingham, A, Paul, L, Robles-Sikisaka, R, Oliveira, G, Pronty, D, Barcellona, C, Metsky, H, Baniecki, M, Barnes, K, Chak, B, Freije, C, Gladden-Young, A, Gnirke, A, Luo, C, MacInnis, B, Matranga, C, Park, D, Qu, J, Schaffner, S, Tomkins-Tinch, C, West, K, Winnicki, S, Wohl, S, Yozwiak, N, Quick, J, Fauver, J, Khan, K, Brent, S, Reiner, R, Lichtenberger, P, Ricciardi, M, Bailey, V, Watkins, D, Cone, M, Kopp, E, Hogan, K, Cannons, A, Jean, R, Monaghan, A, Garry, R, Loman, N, Faria, N, Porcelli, M, Vasquez, C, Nagle, E, Cummings, D, Stanek, D, Rambaut, A, Sanchez-Lockhart, M, Sabeti, P, Gillis, L, Michael, S, Bedford, T, Pybus, O, Isern, S, Palacios, G, Andersen, K
Format: Journal article
Language:English
Published: Springer Nature 2017
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author Grubaugh, N
Ladner, J
Kraemer, M
Dudas, G
Tan, A
Gangavarapu, K
Wiley, M
White, S
Thézé, J
Magnani, D
Prieto, K
Reyes, D
Bingham, A
Paul, L
Robles-Sikisaka, R
Oliveira, G
Pronty, D
Barcellona, C
Metsky, H
Baniecki, M
Barnes, K
Chak, B
Freije, C
Gladden-Young, A
Gnirke, A
Luo, C
MacInnis, B
Matranga, C
Park, D
Qu, J
Schaffner, S
Tomkins-Tinch, C
West, K
Winnicki, S
Wohl, S
Yozwiak, N
Quick, J
Fauver, J
Khan, K
Brent, S
Reiner, R
Lichtenberger, P
Ricciardi, M
Bailey, V
Watkins, D
Cone, M
Kopp, E
Hogan, K
Cannons, A
Jean, R
Monaghan, A
Garry, R
Loman, N
Faria, N
Porcelli, M
Vasquez, C
Nagle, E
Cummings, D
Stanek, D
Rambaut, A
Sanchez-Lockhart, M
Sabeti, P
Gillis, L
Michael, S
Bedford, T
Pybus, O
Isern, S
Palacios, G
Andersen, K
author_facet Grubaugh, N
Ladner, J
Kraemer, M
Dudas, G
Tan, A
Gangavarapu, K
Wiley, M
White, S
Thézé, J
Magnani, D
Prieto, K
Reyes, D
Bingham, A
Paul, L
Robles-Sikisaka, R
Oliveira, G
Pronty, D
Barcellona, C
Metsky, H
Baniecki, M
Barnes, K
Chak, B
Freije, C
Gladden-Young, A
Gnirke, A
Luo, C
MacInnis, B
Matranga, C
Park, D
Qu, J
Schaffner, S
Tomkins-Tinch, C
West, K
Winnicki, S
Wohl, S
Yozwiak, N
Quick, J
Fauver, J
Khan, K
Brent, S
Reiner, R
Lichtenberger, P
Ricciardi, M
Bailey, V
Watkins, D
Cone, M
Kopp, E
Hogan, K
Cannons, A
Jean, R
Monaghan, A
Garry, R
Loman, N
Faria, N
Porcelli, M
Vasquez, C
Nagle, E
Cummings, D
Stanek, D
Rambaut, A
Sanchez-Lockhart, M
Sabeti, P
Gillis, L
Michael, S
Bedford, T
Pybus, O
Isern, S
Palacios, G
Andersen, K
author_sort Grubaugh, N
collection OXFORD
description Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
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spelling oxford-uuid:c63cbe97-2a2d-49d4-a00a-8feae4b8f4962022-03-27T06:36:55ZGenomic epidemiology reveals multiple introductions of Zika virus into the United StatesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c63cbe97-2a2d-49d4-a00a-8feae4b8f496EnglishSymplectic Elements at OxfordSpringer Nature2017Grubaugh, NLadner, JKraemer, MDudas, GTan, AGangavarapu, KWiley, MWhite, SThézé, JMagnani, DPrieto, KReyes, DBingham, APaul, LRobles-Sikisaka, ROliveira, GPronty, DBarcellona, CMetsky, HBaniecki, MBarnes, KChak, BFreije, CGladden-Young, AGnirke, ALuo, CMacInnis, BMatranga, CPark, DQu, JSchaffner, STomkins-Tinch, CWest, KWinnicki, SWohl, SYozwiak, NQuick, JFauver, JKhan, KBrent, SReiner, RLichtenberger, PRicciardi, MBailey, VWatkins, DCone, MKopp, EHogan, KCannons, AJean, RMonaghan, AGarry, RLoman, NFaria, NPorcelli, MVasquez, CNagle, ECummings, DStanek, DRambaut, ASanchez-Lockhart, MSabeti, PGillis, LMichael, SBedford, TPybus, OIsern, SPalacios, GAndersen, KZika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
spellingShingle Grubaugh, N
Ladner, J
Kraemer, M
Dudas, G
Tan, A
Gangavarapu, K
Wiley, M
White, S
Thézé, J
Magnani, D
Prieto, K
Reyes, D
Bingham, A
Paul, L
Robles-Sikisaka, R
Oliveira, G
Pronty, D
Barcellona, C
Metsky, H
Baniecki, M
Barnes, K
Chak, B
Freije, C
Gladden-Young, A
Gnirke, A
Luo, C
MacInnis, B
Matranga, C
Park, D
Qu, J
Schaffner, S
Tomkins-Tinch, C
West, K
Winnicki, S
Wohl, S
Yozwiak, N
Quick, J
Fauver, J
Khan, K
Brent, S
Reiner, R
Lichtenberger, P
Ricciardi, M
Bailey, V
Watkins, D
Cone, M
Kopp, E
Hogan, K
Cannons, A
Jean, R
Monaghan, A
Garry, R
Loman, N
Faria, N
Porcelli, M
Vasquez, C
Nagle, E
Cummings, D
Stanek, D
Rambaut, A
Sanchez-Lockhart, M
Sabeti, P
Gillis, L
Michael, S
Bedford, T
Pybus, O
Isern, S
Palacios, G
Andersen, K
Genomic epidemiology reveals multiple introductions of Zika virus into the United States
title Genomic epidemiology reveals multiple introductions of Zika virus into the United States
title_full Genomic epidemiology reveals multiple introductions of Zika virus into the United States
title_fullStr Genomic epidemiology reveals multiple introductions of Zika virus into the United States
title_full_unstemmed Genomic epidemiology reveals multiple introductions of Zika virus into the United States
title_short Genomic epidemiology reveals multiple introductions of Zika virus into the United States
title_sort genomic epidemiology reveals multiple introductions of zika virus into the united states
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