Genomic epidemiology reveals multiple introductions of Zika virus into the United States
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2017
|
_version_ | 1826295770949615616 |
---|---|
author | Grubaugh, N Ladner, J Kraemer, M Dudas, G Tan, A Gangavarapu, K Wiley, M White, S Thézé, J Magnani, D Prieto, K Reyes, D Bingham, A Paul, L Robles-Sikisaka, R Oliveira, G Pronty, D Barcellona, C Metsky, H Baniecki, M Barnes, K Chak, B Freije, C Gladden-Young, A Gnirke, A Luo, C MacInnis, B Matranga, C Park, D Qu, J Schaffner, S Tomkins-Tinch, C West, K Winnicki, S Wohl, S Yozwiak, N Quick, J Fauver, J Khan, K Brent, S Reiner, R Lichtenberger, P Ricciardi, M Bailey, V Watkins, D Cone, M Kopp, E Hogan, K Cannons, A Jean, R Monaghan, A Garry, R Loman, N Faria, N Porcelli, M Vasquez, C Nagle, E Cummings, D Stanek, D Rambaut, A Sanchez-Lockhart, M Sabeti, P Gillis, L Michael, S Bedford, T Pybus, O Isern, S Palacios, G Andersen, K |
author_facet | Grubaugh, N Ladner, J Kraemer, M Dudas, G Tan, A Gangavarapu, K Wiley, M White, S Thézé, J Magnani, D Prieto, K Reyes, D Bingham, A Paul, L Robles-Sikisaka, R Oliveira, G Pronty, D Barcellona, C Metsky, H Baniecki, M Barnes, K Chak, B Freije, C Gladden-Young, A Gnirke, A Luo, C MacInnis, B Matranga, C Park, D Qu, J Schaffner, S Tomkins-Tinch, C West, K Winnicki, S Wohl, S Yozwiak, N Quick, J Fauver, J Khan, K Brent, S Reiner, R Lichtenberger, P Ricciardi, M Bailey, V Watkins, D Cone, M Kopp, E Hogan, K Cannons, A Jean, R Monaghan, A Garry, R Loman, N Faria, N Porcelli, M Vasquez, C Nagle, E Cummings, D Stanek, D Rambaut, A Sanchez-Lockhart, M Sabeti, P Gillis, L Michael, S Bedford, T Pybus, O Isern, S Palacios, G Andersen, K |
author_sort | Grubaugh, N |
collection | OXFORD |
description | Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions. |
first_indexed | 2024-03-07T04:06:10Z |
format | Journal article |
id | oxford-uuid:c63cbe97-2a2d-49d4-a00a-8feae4b8f496 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T04:06:10Z |
publishDate | 2017 |
publisher | Springer Nature |
record_format | dspace |
spelling | oxford-uuid:c63cbe97-2a2d-49d4-a00a-8feae4b8f4962022-03-27T06:36:55ZGenomic epidemiology reveals multiple introductions of Zika virus into the United StatesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c63cbe97-2a2d-49d4-a00a-8feae4b8f496EnglishSymplectic Elements at OxfordSpringer Nature2017Grubaugh, NLadner, JKraemer, MDudas, GTan, AGangavarapu, KWiley, MWhite, SThézé, JMagnani, DPrieto, KReyes, DBingham, APaul, LRobles-Sikisaka, ROliveira, GPronty, DBarcellona, CMetsky, HBaniecki, MBarnes, KChak, BFreije, CGladden-Young, AGnirke, ALuo, CMacInnis, BMatranga, CPark, DQu, JSchaffner, STomkins-Tinch, CWest, KWinnicki, SWohl, SYozwiak, NQuick, JFauver, JKhan, KBrent, SReiner, RLichtenberger, PRicciardi, MBailey, VWatkins, DCone, MKopp, EHogan, KCannons, AJean, RMonaghan, AGarry, RLoman, NFaria, NPorcelli, MVasquez, CNagle, ECummings, DStanek, DRambaut, ASanchez-Lockhart, MSabeti, PGillis, LMichael, SBedford, TPybus, OIsern, SPalacios, GAndersen, KZika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities. In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida. To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions. |
spellingShingle | Grubaugh, N Ladner, J Kraemer, M Dudas, G Tan, A Gangavarapu, K Wiley, M White, S Thézé, J Magnani, D Prieto, K Reyes, D Bingham, A Paul, L Robles-Sikisaka, R Oliveira, G Pronty, D Barcellona, C Metsky, H Baniecki, M Barnes, K Chak, B Freije, C Gladden-Young, A Gnirke, A Luo, C MacInnis, B Matranga, C Park, D Qu, J Schaffner, S Tomkins-Tinch, C West, K Winnicki, S Wohl, S Yozwiak, N Quick, J Fauver, J Khan, K Brent, S Reiner, R Lichtenberger, P Ricciardi, M Bailey, V Watkins, D Cone, M Kopp, E Hogan, K Cannons, A Jean, R Monaghan, A Garry, R Loman, N Faria, N Porcelli, M Vasquez, C Nagle, E Cummings, D Stanek, D Rambaut, A Sanchez-Lockhart, M Sabeti, P Gillis, L Michael, S Bedford, T Pybus, O Isern, S Palacios, G Andersen, K Genomic epidemiology reveals multiple introductions of Zika virus into the United States |
title | Genomic epidemiology reveals multiple introductions of Zika virus into the United States |
title_full | Genomic epidemiology reveals multiple introductions of Zika virus into the United States |
title_fullStr | Genomic epidemiology reveals multiple introductions of Zika virus into the United States |
title_full_unstemmed | Genomic epidemiology reveals multiple introductions of Zika virus into the United States |
title_short | Genomic epidemiology reveals multiple introductions of Zika virus into the United States |
title_sort | genomic epidemiology reveals multiple introductions of zika virus into the united states |
work_keys_str_mv | AT grubaughn genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT ladnerj genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT kraemerm genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT dudasg genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT tana genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT gangavarapuk genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT wileym genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT whites genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT thezej genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT magnanid genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT prietok genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT reyesd genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT binghama genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT paull genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT roblessikisakar genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT oliveirag genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT prontyd genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT barcellonac genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT metskyh genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT banieckim genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT barnesk genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT chakb genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT freijec genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT gladdenyounga genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT gnirkea genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT luoc genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT macinnisb genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT matrangac genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT parkd genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT quj genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT schaffners genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT tomkinstinchc genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT westk genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT winnickis genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT wohls genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT yozwiakn genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT quickj genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT fauverj genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT khank genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT brents genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT reinerr genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT lichtenbergerp genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT ricciardim genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT baileyv genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT watkinsd genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT conem genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT koppe genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT hogank genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT cannonsa genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT jeanr genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT monaghana genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT garryr genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT lomann genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT farian genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT porcellim genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT vasquezc genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT naglee genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT cummingsd genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT stanekd genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT rambauta genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT sanchezlockhartm genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT sabetip genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT gillisl genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT michaels genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT bedfordt genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT pybuso genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT iserns genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT palaciosg genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates AT andersenk genomicepidemiologyrevealsmultipleintroductionsofzikavirusintotheunitedstates |