NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets

We take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for NKX2-5 wild type and disease associated NKX2-5 mutations to model loss-of-function in gene regulatory networks. NKX2-5 mutants, including those with a crippled ho...

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Bibliographic Details
Main Authors: Bouveret, R, Waardenberg, A, Schonrock, N, Ramialison, M, Doan, T, De Jong, D, Bondue, A, Kaur, G, Mohamed, S, Fonoudi, H, Chen, C, Wouters, M, Bhattacharya, S, Plachta, N, Dunwoodie, S, Chapman, G, Blanpain, C, Harvey, R
Format: Journal article
Language:English
Published: eLife Sciences Publications 2015

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