Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal.
The changes in lipoprotein metabolism which follow the ingestion of a large fat load have been well described. The hypothesis was tested that similar changes in lipoprotein metabolism would occur after a relatively normal meal. Plasma and lipoprotein triacylglycerol, cholesterol and apolipoprotein c...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1797093856558186496 |
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| author | Potts, J Humphreys, S Coppack, S Fisher, R Gibbons, G Frayn, K |
| author_facet | Potts, J Humphreys, S Coppack, S Fisher, R Gibbons, G Frayn, K |
| author_sort | Potts, J |
| collection | OXFORD |
| description | The changes in lipoprotein metabolism which follow the ingestion of a large fat load have been well described. The hypothesis was tested that similar changes in lipoprotein metabolism would occur after a relatively normal meal. Plasma and lipoprotein triacylglycerol, cholesterol and apolipoprotein concentrations were determined in twenty subjects (ten female) given a mixed meal containing approximately one-third of the daily intake of major nutrients in the typical Western diet. Fasting plasma triacylglycerol concentrations (range 0.38-2.70 mm/l) and the postprandial rise in plasma triacylglycerol varied considerably between subjects and were significantly associated (P < 0.01). The rise in plasma triacylglycerol corresponded to marked increases in the triacylglycerol concentration of the triacylglycerol-rich lipoproteins (TRL; chylomicrons and very-low-density lipoproteins). TRL cholesterol also increased after the meal. An increase in high-density-lipoprotein (HDL)-triacylglycerol following the meal was accompanied by a decrease in HDL-cholesterol concentration, presumably due to the action of the cholesteryl-ester transfer protein. The increases in HDL-triacylglycerol and in TRL-cholesterol were correlated with the postprandial rise in triacylglycerol in the TRL (P < 0.01). We conclude that potentially adverse changes occur in both triacylglycerol-rich and high-density lipoproteins following a typical mixed meal, as they do after large fat loads. The changes are exaggerated in those subjects with greater fasting plasma triacylglycerol concentrations. |
| first_indexed | 2024-03-07T04:06:12Z |
| format | Journal article |
| id | oxford-uuid:c6404721-dd05-4dbd-9c05-3dad687102a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:06:12Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:c6404721-dd05-4dbd-9c05-3dad687102a62022-03-27T06:36:46ZFasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c6404721-dd05-4dbd-9c05-3dad687102a6EnglishSymplectic Elements at Oxford1994Potts, JHumphreys, SCoppack, SFisher, RGibbons, GFrayn, KThe changes in lipoprotein metabolism which follow the ingestion of a large fat load have been well described. The hypothesis was tested that similar changes in lipoprotein metabolism would occur after a relatively normal meal. Plasma and lipoprotein triacylglycerol, cholesterol and apolipoprotein concentrations were determined in twenty subjects (ten female) given a mixed meal containing approximately one-third of the daily intake of major nutrients in the typical Western diet. Fasting plasma triacylglycerol concentrations (range 0.38-2.70 mm/l) and the postprandial rise in plasma triacylglycerol varied considerably between subjects and were significantly associated (P < 0.01). The rise in plasma triacylglycerol corresponded to marked increases in the triacylglycerol concentration of the triacylglycerol-rich lipoproteins (TRL; chylomicrons and very-low-density lipoproteins). TRL cholesterol also increased after the meal. An increase in high-density-lipoprotein (HDL)-triacylglycerol following the meal was accompanied by a decrease in HDL-cholesterol concentration, presumably due to the action of the cholesteryl-ester transfer protein. The increases in HDL-triacylglycerol and in TRL-cholesterol were correlated with the postprandial rise in triacylglycerol in the TRL (P < 0.01). We conclude that potentially adverse changes occur in both triacylglycerol-rich and high-density lipoproteins following a typical mixed meal, as they do after large fat loads. The changes are exaggerated in those subjects with greater fasting plasma triacylglycerol concentrations. |
| spellingShingle | Potts, J Humphreys, S Coppack, S Fisher, R Gibbons, G Frayn, K Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal. |
| title | Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal. |
| title_full | Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal. |
| title_fullStr | Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal. |
| title_full_unstemmed | Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal. |
| title_short | Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal. |
| title_sort | fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal |
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