Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm
Objectives: Ovarian cancer screening for women at increased genetic risk in the UK involves 4-monthly CA125 tests and annual ultrasound, with further tests prompted by an abnormal result. The study evaluated the longer-term psychological and behavioural effects of frequent ovarian screening. Methods...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797093875225985024 |
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| author | Brain, K Lifford, K Fraser, L Rosenthal, A Rogers, M Lancastle, D Phelps, C Watson, E Clements, A Menon, U |
| author_facet | Brain, K Lifford, K Fraser, L Rosenthal, A Rogers, M Lancastle, D Phelps, C Watson, E Clements, A Menon, U |
| author_sort | Brain, K |
| collection | OXFORD |
| description | Objectives: Ovarian cancer screening for women at increased genetic risk in the UK involves 4-monthly CA125 tests and annual ultrasound, with further tests prompted by an abnormal result. The study evaluated the longer-term psychological and behavioural effects of frequent ovarian screening. Methods: Women completed T1 questionnaires before their first routine 4-monthly CA125 test, and T2 follow-up questionnaires one week after their result. Women with abnormal results completed a further questionnaire one week after return to routine screening (T3 primary end-point). T4 questionnaires were sent at nine months. Measures included cancer distress, general anxiety/depression, reassurance, and withdrawal from screening. Results: A total 1999 (62%) of 3224 women completed T1 questionnaires. T2 questionnaires were completed by 1384/1609 participants (86%): 1217 (89%) with normal results and 167/242 (69%) with abnormal results. T3 questionnaires were completed by 141/163 (87%) women, with 912/1173 (78%) completing T4 questionnaires. Analysis of covariance indicated that, compared to women with normal results, women with abnormal results reported moderate cancer distress (F = 27.47, p ≤.001, η2 = 0.02) one week after their abnormal result and were significantly more likely to withdraw from screening (OR = 4.38, p ≤.001). These effects were not apparent at T3 or T4. The effect of screening result on general anxiety/depression or overall reassurance was not significant. Conclusions: Women participating in frequent ovarian screening who are recalled for an abnormal result may experience transient cancer-specific distress, which may prompt reconsideration of risk management options. Health professionals and policy makers may be reassured that frequent familial ovarian screening does not cause sustained psychological harm. © 2012 Elsevier Inc. All rights reserved. |
| first_indexed | 2024-03-07T04:06:26Z |
| format | Journal article |
| id | oxford-uuid:c656f57c-11b3-4e5e-b76b-6a666ca525ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:06:26Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:c656f57c-11b3-4e5e-b76b-6a666ca525ab2022-03-27T06:37:17ZPsychological outcomes of familial ovarian cancer screening: No evidence of long-term harmJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c656f57c-11b3-4e5e-b76b-6a666ca525abEnglishSymplectic Elements at Oxford2012Brain, KLifford, KFraser, LRosenthal, ARogers, MLancastle, DPhelps, CWatson, EClements, AMenon, UObjectives: Ovarian cancer screening for women at increased genetic risk in the UK involves 4-monthly CA125 tests and annual ultrasound, with further tests prompted by an abnormal result. The study evaluated the longer-term psychological and behavioural effects of frequent ovarian screening. Methods: Women completed T1 questionnaires before their first routine 4-monthly CA125 test, and T2 follow-up questionnaires one week after their result. Women with abnormal results completed a further questionnaire one week after return to routine screening (T3 primary end-point). T4 questionnaires were sent at nine months. Measures included cancer distress, general anxiety/depression, reassurance, and withdrawal from screening. Results: A total 1999 (62%) of 3224 women completed T1 questionnaires. T2 questionnaires were completed by 1384/1609 participants (86%): 1217 (89%) with normal results and 167/242 (69%) with abnormal results. T3 questionnaires were completed by 141/163 (87%) women, with 912/1173 (78%) completing T4 questionnaires. Analysis of covariance indicated that, compared to women with normal results, women with abnormal results reported moderate cancer distress (F = 27.47, p ≤.001, η2 = 0.02) one week after their abnormal result and were significantly more likely to withdraw from screening (OR = 4.38, p ≤.001). These effects were not apparent at T3 or T4. The effect of screening result on general anxiety/depression or overall reassurance was not significant. Conclusions: Women participating in frequent ovarian screening who are recalled for an abnormal result may experience transient cancer-specific distress, which may prompt reconsideration of risk management options. Health professionals and policy makers may be reassured that frequent familial ovarian screening does not cause sustained psychological harm. © 2012 Elsevier Inc. All rights reserved. |
| spellingShingle | Brain, K Lifford, K Fraser, L Rosenthal, A Rogers, M Lancastle, D Phelps, C Watson, E Clements, A Menon, U Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm |
| title | Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm |
| title_full | Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm |
| title_fullStr | Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm |
| title_full_unstemmed | Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm |
| title_short | Psychological outcomes of familial ovarian cancer screening: No evidence of long-term harm |
| title_sort | psychological outcomes of familial ovarian cancer screening no evidence of long term harm |
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