123I-labeled HIV-1 tat peptide radioimmunoconjugates are imported into the nucleus of human breast cancer cells and functionally interact in vitro and in vivo with the cyclin-dependent kinase inhibitor, p21(WAF-1/Cip-1).

PURPOSE: To evaluate the internalization and nuclear translocation of (123)I-tat-peptide radioimmunoconjugates in MDA-MB-468 breast cancer cells and their ability to interact with the cyclin-dependent kinase inhibitor, p21(WAF-1/Cip-1). METHODS: Peptides [GRKKRRQRRRPPQGYGC] harboring the nuclear-loc...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Hu, M, Chen, P, Wang, J, Scollard, D, Vallis, K, Reilly, R
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2007