Measurement of mismatch negativity in individuals: a study using single-trial analysis.
Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826295793489805312 |
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| author | Bishop, D Hardiman, M |
| author_facet | Bishop, D Hardiman, M |
| author_sort | Bishop, D |
| collection | OXFORD |
| description | Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial-by-trial variance are first removed. Next, each deviant response has the preceding standard response subtracted, giving a set of single trial difference waves. We illustrate this approach in analysis of MMN to brief tones in 17 adults. The best criterion for MMN combined t-test with an index of inter-trial coherence, giving significant MMN in 14 (82%) of individuals. Single-trial methods can indicate which people show MMN. However, in some clinically normal individuals there was no MMN, despite good behavioral discrimination of stimuli. |
| first_indexed | 2024-03-07T04:06:31Z |
| format | Journal article |
| id | oxford-uuid:c65c6fb6-08e4-4b21-8429-4ba5e1120402 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:06:31Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:c65c6fb6-08e4-4b21-8429-4ba5e11204022022-03-27T06:37:29ZMeasurement of mismatch negativity in individuals: a study using single-trial analysis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c65c6fb6-08e4-4b21-8429-4ba5e1120402EnglishSymplectic Elements at Oxford2010Bishop, DHardiman, MMismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial-by-trial variance are first removed. Next, each deviant response has the preceding standard response subtracted, giving a set of single trial difference waves. We illustrate this approach in analysis of MMN to brief tones in 17 adults. The best criterion for MMN combined t-test with an index of inter-trial coherence, giving significant MMN in 14 (82%) of individuals. Single-trial methods can indicate which people show MMN. However, in some clinically normal individuals there was no MMN, despite good behavioral discrimination of stimuli. |
| spellingShingle | Bishop, D Hardiman, M Measurement of mismatch negativity in individuals: a study using single-trial analysis. |
| title | Measurement of mismatch negativity in individuals: a study using single-trial analysis. |
| title_full | Measurement of mismatch negativity in individuals: a study using single-trial analysis. |
| title_fullStr | Measurement of mismatch negativity in individuals: a study using single-trial analysis. |
| title_full_unstemmed | Measurement of mismatch negativity in individuals: a study using single-trial analysis. |
| title_short | Measurement of mismatch negativity in individuals: a study using single-trial analysis. |
| title_sort | measurement of mismatch negativity in individuals a study using single trial analysis |
| work_keys_str_mv | AT bishopd measurementofmismatchnegativityinindividualsastudyusingsingletrialanalysis AT hardimanm measurementofmismatchnegativityinindividualsastudyusingsingletrialanalysis |