Is type 2 diabetes a glycogen storage disease of pancreatic β cells?
Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-exam...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2017
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| _version_ | 1826295818984882176 |
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| author | Ashcroft, F Rohm, M Clark, A Brereton, M |
| author_facet | Ashcroft, F Rohm, M Clark, A Brereton, M |
| author_sort | Ashcroft, F |
| collection | OXFORD |
| description | Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes. |
| first_indexed | 2024-03-07T04:06:53Z |
| format | Journal article |
| id | oxford-uuid:c67923bf-3699-4e49-a6a0-864080a26366 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:06:53Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:c67923bf-3699-4e49-a6a0-864080a263662022-03-27T06:38:22ZIs type 2 diabetes a glycogen storage disease of pancreatic β cells?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c67923bf-3699-4e49-a6a0-864080a26366EnglishSymplectic Elements at OxfordElsevier2017Ashcroft, FRohm, MClark, ABrereton, MElevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting β cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in β cells in normoglycemia and in diabetes. |
| spellingShingle | Ashcroft, F Rohm, M Clark, A Brereton, M Is type 2 diabetes a glycogen storage disease of pancreatic β cells? |
| title | Is type 2 diabetes a glycogen storage disease of pancreatic β cells? |
| title_full | Is type 2 diabetes a glycogen storage disease of pancreatic β cells? |
| title_fullStr | Is type 2 diabetes a glycogen storage disease of pancreatic β cells? |
| title_full_unstemmed | Is type 2 diabetes a glycogen storage disease of pancreatic β cells? |
| title_short | Is type 2 diabetes a glycogen storage disease of pancreatic β cells? |
| title_sort | is type 2 diabetes a glycogen storage disease of pancreatic β cells |
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