Vasomodulation of skeletal muscle BOLD signal.
PURPOSE: To evaluate whether the BOLD signal from skeletal muscle can be modulated by exercise and ingestion of vasoactive substances. MATERIALS AND METHODS: The right calf muscles of healthy adult volunteers were imaged using a GE 1.5-Tesla scanner and a gradient-echo sequence with spiral readout....
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1826295825192452096 |
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| author | Bulte, D Alfonsi, J Bells, S Noseworthy, MD |
| author_facet | Bulte, D Alfonsi, J Bells, S Noseworthy, MD |
| author_sort | Bulte, D |
| collection | OXFORD |
| description | PURPOSE: To evaluate whether the BOLD signal from skeletal muscle can be modulated by exercise and ingestion of vasoactive substances. MATERIALS AND METHODS: The right calf muscles of healthy adult volunteers were imaged using a GE 1.5-Tesla scanner and a gradient-echo sequence with spiral readout. Time-varying changes in the BOLD signal were induced through cyclic phases of normoxia (90 seconds of 20.8% O2) and hyperoxia (45 seconds of 100% O2 at 22 L/minute). Superimposed on this paradigm were pre- and post-exercise regimes, with and without ingestion of caffeine (100 mg) or antihistamine (4 mg chlorpheniramine). The numbers of voxels within slow-twitch (soleus) and fast-twitch (gastrocnemius) muscles that significantly responded to the paradigms were scored and compared using the AFNI software (NIMH). RESULTS: Cycling-inspired O2 produced a corresponding BOLD modulation that increased in magnitude with exercise. Chlorpheniramine significantly (P<0.01) prevented the overall increase in exercise-induced soleus muscle BOLD signal, while caffeine accentuated the increase (P<0.05) in the gastrocnemius relative to control (no vasomodulator) conditions. CONCLUSION: BOLD signal changes with exercise can be modulated by standard doses of chlorpheniramine (antihistamine) and caffeine. We suggest that chlorpheniramine may act detrimentally on slow-twitch muscle contractility, while caffeine appears to improve fast-twitch muscle function. |
| first_indexed | 2024-03-07T04:06:58Z |
| format | Journal article |
| id | oxford-uuid:c67fb8df-ef2b-419c-a59d-fd94e51abfce |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:06:58Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:c67fb8df-ef2b-419c-a59d-fd94e51abfce2022-03-27T06:38:40ZVasomodulation of skeletal muscle BOLD signal.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c67fb8df-ef2b-419c-a59d-fd94e51abfceEnglishSymplectic Elements at Oxford2006Bulte, DAlfonsi, JBells, SNoseworthy, MD PURPOSE: To evaluate whether the BOLD signal from skeletal muscle can be modulated by exercise and ingestion of vasoactive substances. MATERIALS AND METHODS: The right calf muscles of healthy adult volunteers were imaged using a GE 1.5-Tesla scanner and a gradient-echo sequence with spiral readout. Time-varying changes in the BOLD signal were induced through cyclic phases of normoxia (90 seconds of 20.8% O2) and hyperoxia (45 seconds of 100% O2 at 22 L/minute). Superimposed on this paradigm were pre- and post-exercise regimes, with and without ingestion of caffeine (100 mg) or antihistamine (4 mg chlorpheniramine). The numbers of voxels within slow-twitch (soleus) and fast-twitch (gastrocnemius) muscles that significantly responded to the paradigms were scored and compared using the AFNI software (NIMH). RESULTS: Cycling-inspired O2 produced a corresponding BOLD modulation that increased in magnitude with exercise. Chlorpheniramine significantly (P<0.01) prevented the overall increase in exercise-induced soleus muscle BOLD signal, while caffeine accentuated the increase (P<0.05) in the gastrocnemius relative to control (no vasomodulator) conditions. CONCLUSION: BOLD signal changes with exercise can be modulated by standard doses of chlorpheniramine (antihistamine) and caffeine. We suggest that chlorpheniramine may act detrimentally on slow-twitch muscle contractility, while caffeine appears to improve fast-twitch muscle function. |
| spellingShingle | Bulte, D Alfonsi, J Bells, S Noseworthy, MD Vasomodulation of skeletal muscle BOLD signal. |
| title | Vasomodulation of skeletal muscle BOLD signal. |
| title_full | Vasomodulation of skeletal muscle BOLD signal. |
| title_fullStr | Vasomodulation of skeletal muscle BOLD signal. |
| title_full_unstemmed | Vasomodulation of skeletal muscle BOLD signal. |
| title_short | Vasomodulation of skeletal muscle BOLD signal. |
| title_sort | vasomodulation of skeletal muscle bold signal |
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