Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

SF3B1, SRSF2 and U2AF1 are the most frequently mutated splicing factor genes in the myelodysplastic syndromes (MDS). We have performed a comprehensive and systematic analysis to determine the impact of these commonly mutated splicing factors on pre-mRNA splicing in the bone marrow stem/progenitor ce...

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Bibliografiska uppgifter
Huvudupphovsmän:	Pellagatti, A, Armstrong, R, Steeples, V, Sharma, E, Repapi, E, Singh, S, Sanchi, A, Radujkovic, A, Horn, P, Dolatshad, H, Roy, S, Broxholme, J, Lockstone, H, Taylor, S, Giagounidis, A, Vyas, P, Schuh, A, Hamblin, A, Papaemmanuil, E, Killick, S, Malcovati, L, Hennrich, M, Gavin, A, Ho, A, Luft, T, Hellström-Lindberg, E, Cazzola, M, Smith, C, Smith, S, Boultwood, J
Materialtyp:	Journal article
Språk:	English
Publicerad:	American Society of Hematology 2018

Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

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