Lack of interferon induction in man by two rabies tissue culture vaccines.
Both neutralising antibody and interferon play a part in protection of animals against death from rabies virus infection. Interferon induction was therefore sought in 53 volunteers within 24 hours of receiving human diploid cell strain vaccine or fetal bovine kidney cell vaccine given either intramu...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1985
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| _version_ | 1797093985225801728 |
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| author | Chanthavanich, P Warrell, M Looareesuwan, S Karbwang, J Phillips, R Supanaranond, W Vejcho, S Rollin, P Sureau, P Warrell, D |
| author_facet | Chanthavanich, P Warrell, M Looareesuwan, S Karbwang, J Phillips, R Supanaranond, W Vejcho, S Rollin, P Sureau, P Warrell, D |
| author_sort | Chanthavanich, P |
| collection | OXFORD |
| description | Both neutralising antibody and interferon play a part in protection of animals against death from rabies virus infection. Interferon induction was therefore sought in 53 volunteers within 24 hours of receiving human diploid cell strain vaccine or fetal bovine kidney cell vaccine given either intramuscularly or intradermally. Repeat observations were made in 18 subjects following a second dose of vaccine seven days later. No interferon was detected in any sample tested although no subject had any detectable rabies neutralising antibody on day 0. The sensitivity of the interferon assay, and comparison with other studies are discussed. An interferon inducer suitable for human use should be sought as an alternative to, or a replacement for, passive rabies immunization. |
| first_indexed | 2024-03-07T04:07:54Z |
| format | Journal article |
| id | oxford-uuid:c6d72da5-61ae-4070-90d7-d915ba2e626e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:07:54Z |
| publishDate | 1985 |
| record_format | dspace |
| spelling | oxford-uuid:c6d72da5-61ae-4070-90d7-d915ba2e626e2022-03-27T06:40:45ZLack of interferon induction in man by two rabies tissue culture vaccines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c6d72da5-61ae-4070-90d7-d915ba2e626eEnglishSymplectic Elements at Oxford1985Chanthavanich, PWarrell, MLooareesuwan, SKarbwang, JPhillips, RSupanaranond, WVejcho, SRollin, PSureau, PWarrell, DBoth neutralising antibody and interferon play a part in protection of animals against death from rabies virus infection. Interferon induction was therefore sought in 53 volunteers within 24 hours of receiving human diploid cell strain vaccine or fetal bovine kidney cell vaccine given either intramuscularly or intradermally. Repeat observations were made in 18 subjects following a second dose of vaccine seven days later. No interferon was detected in any sample tested although no subject had any detectable rabies neutralising antibody on day 0. The sensitivity of the interferon assay, and comparison with other studies are discussed. An interferon inducer suitable for human use should be sought as an alternative to, or a replacement for, passive rabies immunization. |
| spellingShingle | Chanthavanich, P Warrell, M Looareesuwan, S Karbwang, J Phillips, R Supanaranond, W Vejcho, S Rollin, P Sureau, P Warrell, D Lack of interferon induction in man by two rabies tissue culture vaccines. |
| title | Lack of interferon induction in man by two rabies tissue culture vaccines. |
| title_full | Lack of interferon induction in man by two rabies tissue culture vaccines. |
| title_fullStr | Lack of interferon induction in man by two rabies tissue culture vaccines. |
| title_full_unstemmed | Lack of interferon induction in man by two rabies tissue culture vaccines. |
| title_short | Lack of interferon induction in man by two rabies tissue culture vaccines. |
| title_sort | lack of interferon induction in man by two rabies tissue culture vaccines |
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