Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor.

BACKGROUND: In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa. We characterized the substrate specificity and zinc-mediated inhibition of PSA. METHODS: The proteolysis of human semenogelin I...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Malm, J, Hellman, J, Hogg, P, Lilja, H
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2000