Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells
The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2018
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| _version_ | 1797093993388965888 |
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| author | Dyson, J Foll, F Magal, P Noussair, A Pasquier, J |
| author_facet | Dyson, J Foll, F Magal, P Noussair, A Pasquier, J |
| author_sort | Dyson, J |
| collection | OXFORD |
| description | The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results. |
| first_indexed | 2024-03-07T04:08:01Z |
| format | Journal article |
| id | oxford-uuid:c6e13b7f-10a1-4cb8-a103-f5c7959f8497 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:08:01Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:c6e13b7f-10a1-4cb8-a103-f5c7959f84972022-03-27T06:41:00ZDirect and indirect P-glycoprotein transfers in MCF7 breast cancer cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c6e13b7f-10a1-4cb8-a103-f5c7959f8497EnglishSymplectic Elements at OxfordElsevier2018Dyson, JFoll, FMagal, PNoussair, APasquier, JThe efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results. |
| spellingShingle | Dyson, J Foll, F Magal, P Noussair, A Pasquier, J Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells |
| title | Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells |
| title_full | Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells |
| title_fullStr | Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells |
| title_full_unstemmed | Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells |
| title_short | Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells |
| title_sort | direct and indirect p glycoprotein transfers in mcf7 breast cancer cells |
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