Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Small-molecule inhibitors that target bromodomains outside of the bromodomain and extra-terminal (BET) sub-family are lacking. Here, we describe highly potent and selective ligands for the bromodomain module of the human lysine acetyl transferase CBP/p300, developed from a series of 5-isoxazolyl-ben...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Hay, D, Fedorov, O, Martin, S, Singleton, D, Tallant, C, Wells, C, Picaud, S, Philpott, M, Monteiro, O, Rogers, C, Conway, S, Rooney, T, Tumber, A, Yapp, C, Filippakopoulos, P, Bunnage, M, Müller, S, Knapp, S, Schofield, C, Brennan, P
التنسيق: Journal article
اللغة:English
منشور في: American Chemical Society 2014

مواد مشابهة

مواد مشابهة