Intercellular induction of apoptosis signalling pathways.
Intercellular signalling plays an important role in the progression of a transformed cell to a tumour. In order to characterise the underlying mechanisms, a well-defined model cell system of intercellular induction of apoptosis was used where neighbouring normal cells can selectively eliminate trans...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826295924611088384 |
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| author | Abdelrazzak, AB O'Neill, P Hill, M |
| author_facet | Abdelrazzak, AB O'Neill, P Hill, M |
| author_sort | Abdelrazzak, AB |
| collection | OXFORD |
| description | Intercellular signalling plays an important role in the progression of a transformed cell to a tumour. In order to characterise the underlying mechanisms, a well-defined model cell system of intercellular induction of apoptosis was used where neighbouring normal cells can selectively eliminate transformed cells. In the absence of non-transformed cells, the induction of apoptosis in transformed 208Fsrc3 cells occurs via autocrine destruction and is dominated by peroxidase (PO), which initiates the PO/hypochlorous acid signalling pathway at high local cell densities. However, when the transformed cells are co-cultured with the non-transformed 208F cells, apoptosis in transformed cells additionally occurs as a result of intercellular signalling with the non-transformed cells and is predominantly due to the production of nitric oxide (NO(•)), which initiates the NO(•)/peroxynitrite pathway. |
| first_indexed | 2024-03-07T04:08:27Z |
| format | Journal article |
| id | oxford-uuid:c7004152-1265-4fed-972b-f0a050e89555 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:08:27Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:c7004152-1265-4fed-972b-f0a050e895552022-03-27T06:41:55ZIntercellular induction of apoptosis signalling pathways.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7004152-1265-4fed-972b-f0a050e89555EnglishSymplectic Elements at Oxford2011Abdelrazzak, ABO'Neill, PHill, MIntercellular signalling plays an important role in the progression of a transformed cell to a tumour. In order to characterise the underlying mechanisms, a well-defined model cell system of intercellular induction of apoptosis was used where neighbouring normal cells can selectively eliminate transformed cells. In the absence of non-transformed cells, the induction of apoptosis in transformed 208Fsrc3 cells occurs via autocrine destruction and is dominated by peroxidase (PO), which initiates the PO/hypochlorous acid signalling pathway at high local cell densities. However, when the transformed cells are co-cultured with the non-transformed 208F cells, apoptosis in transformed cells additionally occurs as a result of intercellular signalling with the non-transformed cells and is predominantly due to the production of nitric oxide (NO(•)), which initiates the NO(•)/peroxynitrite pathway. |
| spellingShingle | Abdelrazzak, AB O'Neill, P Hill, M Intercellular induction of apoptosis signalling pathways. |
| title | Intercellular induction of apoptosis signalling pathways. |
| title_full | Intercellular induction of apoptosis signalling pathways. |
| title_fullStr | Intercellular induction of apoptosis signalling pathways. |
| title_full_unstemmed | Intercellular induction of apoptosis signalling pathways. |
| title_short | Intercellular induction of apoptosis signalling pathways. |
| title_sort | intercellular induction of apoptosis signalling pathways |
| work_keys_str_mv | AT abdelrazzakab intercellularinductionofapoptosissignallingpathways AT oneillp intercellularinductionofapoptosissignallingpathways AT hillm intercellularinductionofapoptosissignallingpathways |