The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis
<p><strong>Background:</strong> Restricted activity is a potential early marker of declining health in older adults. Previous studies of this association with patient outcomes have been inconclusive. This review aimed to evaluate the extent to which restricted activity is...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2024
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| _version_ | 1826313315736879104 |
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| author | Henderson, IL Bone, RW Stevens, R Barnes, RK Roberts, N Sheppard, JP McManus, RJ |
| author_facet | Henderson, IL Bone, RW Stevens, R Barnes, RK Roberts, N Sheppard, JP McManus, RJ |
| author_sort | Henderson, IL |
| collection | OXFORD |
| description | <p><strong>Background:</strong> Restricted activity is a potential early marker of declining health in older adults. Previous studies of this association with patient outcomes have been inconclusive. This review aimed to evaluate the extent to which restricted activity is associated with decline in health.</p>
<p><strong>Methods:</strong> A search was conducted for studies including people over 65 years old which investigated the association between measures of restricted activity and hospitalisation, cognitive decline, and mortality. Following data extraction by two reviewers, eligible studies were summarised using Inverse Variance Heterogeneity meta-analysis.</p>
<p><strong>Results:</strong> The search identified 8,434 unique publications, with 11 eligible studies. Three measures of restricted activity were identified: bed rest, restricted movement, and dependency for activities of daily living (ADL). Three studies looked at hospitalisations, with two finding a significant association with bed rest or restricted movement and one showing no evidence of an association. Restricted activity was associated with a significant increase in mortality across all three measures (bed rest odds ratio [OR] 6.34, 95%CI 2.51–16.02, I2 = 76%; restricted movement OR 5.38 95%CI 2.60–11.13, I2 = 69%; general ADL dependency OR 4.65 95%CI 2.25–9.26, I2 = 84%). The significant heterogeneity observed could not be explained by restricting the analysis by length of follow-up, or measure of restricted activity. No meta-analysis was conducted on the limited evidence for cognitive decline outcomes.</p>
<p><strong>Conclusions:</strong> Limited studies have considered the prognostic value of restricted activity in terms of predicting future declining health. Current evidence suggests restricted activity is associated with hospitalisation and mortality, and therefore could identify a group for whom early intervention might be possible.</p> |
| first_indexed | 2024-09-25T04:11:05Z |
| format | Journal article |
| id | oxford-uuid:c70320a2-6310-4deb-8f1e-63121569bee8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:11:05Z |
| publishDate | 2024 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:c70320a2-6310-4deb-8f1e-63121569bee82024-06-17T11:19:27ZThe association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c70320a2-6310-4deb-8f1e-63121569bee8EnglishSymplectic ElementsBioMed Central2024Henderson, ILBone, RWStevens, RBarnes, RKRoberts, NSheppard, JPMcManus, RJ<p><strong>Background:</strong> Restricted activity is a potential early marker of declining health in older adults. Previous studies of this association with patient outcomes have been inconclusive. This review aimed to evaluate the extent to which restricted activity is associated with decline in health.</p> <p><strong>Methods:</strong> A search was conducted for studies including people over 65 years old which investigated the association between measures of restricted activity and hospitalisation, cognitive decline, and mortality. Following data extraction by two reviewers, eligible studies were summarised using Inverse Variance Heterogeneity meta-analysis.</p> <p><strong>Results:</strong> The search identified 8,434 unique publications, with 11 eligible studies. Three measures of restricted activity were identified: bed rest, restricted movement, and dependency for activities of daily living (ADL). Three studies looked at hospitalisations, with two finding a significant association with bed rest or restricted movement and one showing no evidence of an association. Restricted activity was associated with a significant increase in mortality across all three measures (bed rest odds ratio [OR] 6.34, 95%CI 2.51–16.02, I2 = 76%; restricted movement OR 5.38 95%CI 2.60–11.13, I2 = 69%; general ADL dependency OR 4.65 95%CI 2.25–9.26, I2 = 84%). The significant heterogeneity observed could not be explained by restricting the analysis by length of follow-up, or measure of restricted activity. No meta-analysis was conducted on the limited evidence for cognitive decline outcomes.</p> <p><strong>Conclusions:</strong> Limited studies have considered the prognostic value of restricted activity in terms of predicting future declining health. Current evidence suggests restricted activity is associated with hospitalisation and mortality, and therefore could identify a group for whom early intervention might be possible.</p> |
| spellingShingle | Henderson, IL Bone, RW Stevens, R Barnes, RK Roberts, N Sheppard, JP McManus, RJ The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis |
| title | The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis |
| title_full | The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis |
| title_fullStr | The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis |
| title_full_unstemmed | The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis |
| title_short | The association between restricted activity and patient outcomes in older adults: systematic literature review and meta-analysis |
| title_sort | association between restricted activity and patient outcomes in older adults systematic literature review and meta analysis |
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