Epigenetic programming defines haematopoietic stem cell fate restriction

Epigenetic programming defines haematopoietic stem cell fate restriction

Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is epigenetically but not transcriptionally primed in H...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Meng, Y, de Teixeira Carrelha, J, Drissen, R, Ren, X, Zhang, B, Gambardella, A, Valletta, S, Thongjuea, S, Jacobsen, SE, Nerlov, C
Natura:	Journal article
Lingua:	English
Pubblicazione:	Springer Nature 2023

Documenti analoghi

The road not taken: lineage bias and restriction of haematopoietic stem and progenitor cells
di: de Teixeira Carrelha, J
Pubblicazione: (2016)

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
di: Amit Grover, et al.
Pubblicazione: (2016-03-01)

Hierarchically related lineage-restricted fates by multipotent hematopoietic stem cells
di: Carrelha, C, et al.
Pubblicazione: (2018)

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.
di: Sanjuan-Pla, A, et al.
Pubblicazione: (2013)

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
di: Sanjuan-Pla, A, et al.
Pubblicazione: (2013)

Single cell RNA sequencing reveals molecular and functional platelet bias of aged hematopoietic stem cells
di: Nerlov, C, et al.
Pubblicazione: (2016)

The emergence and early fate decisions of stem and progenitor cells in the haematopoietic system
di: Lutteropp, M
Pubblicazione: (2012)

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
di: Nicola Vannini, et al.
Pubblicazione: (2016-10-01)

TLRs direct haematopoietic precursor fate
di: Downes, J, et al.
Pubblicazione: (2007)

Identification of two distinct pathways of human myelopoiesis
di: Drissen, R, et al.
Pubblicazione: (2019)

Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
di: Fizzah Aziz Choudry, et al.
Pubblicazione: (2016-01-01)

FLT3-ITD INDUCED MYELOPROLIFERATION CAUSES A CELL EXTRINSIC DEPLETION OF HAEMATOPOIETIC STEM CELLS
di: Mead, A, et al.
Pubblicazione: (2014)

Chemically defined cytokine-free expansion of human haematopoietic stem cells
di: Sakurai, M, et al.
Pubblicazione: (2023)

PU.1 and Haematopoietic Cell Fate: Dosage Matters
di: Ka Sin Mak, et al.
Pubblicazione: (2011-01-01)

Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies
di: Sonja C. Buisman, et al.
Pubblicazione: (2019-08-01)

Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges.
di: Buza-Vidas, N, et al.
Pubblicazione: (2007)

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
di: Valletta, S, et al.
Pubblicazione: (2020)

Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function
di: Ryan J. Smith, et al.
Pubblicazione: (2023-01-01)

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.
di: Pouget, C, et al.
Pubblicazione: (2014)

P1411: DUAL EPIGENETIC AND GENETIC EDITING OF PRIMARY HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELLS
di: E. Saunderson, et al.
Pubblicazione: (2022-06-01)

Epigenetic Regulation of Dental Pulp Stem Cell Fate
di: Dan Zhou, et al.
Pubblicazione: (2020-01-01)

The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
di: Andrew J. Lilly, et al.
Pubblicazione: (2011-01-01)

Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
di: Xinxin Huang, et al.
Pubblicazione: (2018-07-01)

The Impact of Epigenetic Signatures on Amniotic Fluid Stem Cell Fate
di: Daniela Di Tizio, et al.
Pubblicazione: (2018-01-01)

Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell Fate Transitions
di: Li Sun, et al.
Pubblicazione: (2021-02-01)

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
di: Simona Valletta, et al.
Pubblicazione: (2020-08-01)

Haematopoietic stem cell transplantation in Switzerland
di: Swiss Medical Weekly
Pubblicazione: (2006-01-01)

In utero haematopoietic stem cell transplantation
di: C Troeger, et al.
Pubblicazione: (2006-08-01)

Dynamics of Haematopoietic Stem Cells Model
di: Julia Stoberova
Pubblicazione: (2012-09-01)

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
di: Di Genua, C, et al.
Pubblicazione: (2019)

S128: AML CONDITIONING OF THE BONE MARROW MICROENVIRONMENT THROUGH CCR1 LIGAND UP-REGULATION PROMOTES AML STEM CELL PROPAGATION AND IS MIMICKED BY AGEING
di: Xiying Ren, et al.
Pubblicazione: (2023-08-01)

Hematopoietic lineage diversification, simplified
di: Drissen, R, et al.
Pubblicazione: (2016)

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
di: Nygren, J, et al.
Pubblicazione: (2008)

P1403: ENDOMUCIN IS A MARKER OF QUIESCENT HAEMATOPOIETIC STEM CELLS WITH HIGH LONG-TERM ENGRAFTMENT CAPACITY
di: S. Engelhard, et al.
Pubblicazione: (2022-06-01)

Distinct myeloid progenitor differentiation pathways identified through single cell RNA sequencing
di: Drissen, R, et al.
Pubblicazione: (2016)

Reconstruction of Human AML Using Functionally and Immunophenotypically Defined Human Haematopoietic Stem and Progenitor Cells as Targeted Populations
di: Bernd Zeisig, et al.
Pubblicazione: (2021-12-01)

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells
di: Hui Zhang, et al.
Pubblicazione: (2022-01-01)

JMJD3: a critical epigenetic regulator in stem cell fate
di: Yuanjie Ding, et al.
Pubblicazione: (2021-07-01)

Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
di: Alicja Walewska, et al.
Pubblicazione: (2023-11-01)

IN UTERO HAEMATOPOIETIC STEM CELL TRANSPLANTATION (IUHSCT)
di: Maria Concetta Renda, et al.
Pubblicazione: (2009-12-01)