Epigenetic programming defines haematopoietic stem cell fate restriction

Epigenetic programming defines haematopoietic stem cell fate restriction

Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is epigenetically but not transcriptionally primed in H...

書誌詳細
主要な著者:	Meng, Y, de Teixeira Carrelha, J, Drissen, R, Ren, X, Zhang, B, Gambardella, A, Valletta, S, Thongjuea, S, Jacobsen, SE, Nerlov, C
フォーマット:	Journal article
言語:	English
出版事項:	Springer Nature 2023

類似資料

The road not taken: lineage bias and restriction of haematopoietic stem and progenitor cells
著者:: de Teixeira Carrelha, J
出版事項: (2016)

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
著者:: Amit Grover, 等
出版事項: (2016-03-01)

Hierarchically related lineage-restricted fates by multipotent hematopoietic stem cells
著者:: Carrelha, C, 等
出版事項: (2018)

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.
著者:: Sanjuan-Pla, A, 等
出版事項: (2013)

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
著者:: Sanjuan-Pla, A, 等
出版事項: (2013)

Single cell RNA sequencing reveals molecular and functional platelet bias of aged hematopoietic stem cells
著者:: Nerlov, C, 等
出版事項: (2016)

The emergence and early fate decisions of stem and progenitor cells in the haematopoietic system
著者:: Lutteropp, M
出版事項: (2012)

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
著者:: Nicola Vannini, 等
出版事項: (2016-10-01)

TLRs direct haematopoietic precursor fate
著者:: Downes, J, 等
出版事項: (2007)

Identification of two distinct pathways of human myelopoiesis
著者:: Drissen, R, 等
出版事項: (2019)

Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
著者:: Fizzah Aziz Choudry, 等
出版事項: (2016-01-01)

FLT3-ITD INDUCED MYELOPROLIFERATION CAUSES A CELL EXTRINSIC DEPLETION OF HAEMATOPOIETIC STEM CELLS
著者:: Mead, A, 等
出版事項: (2014)

Chemically defined cytokine-free expansion of human haematopoietic stem cells
著者:: Sakurai, M, 等
出版事項: (2023)

PU.1 and Haematopoietic Cell Fate: Dosage Matters
著者:: Ka Sin Mak, 等
出版事項: (2011-01-01)

Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies
著者:: Sonja C. Buisman, 等
出版事項: (2019-08-01)

Delineation of the earliest lineage commitment steps of haematopoietic stem cells: new developments, controversies and major challenges.
著者:: Buza-Vidas, N, 等
出版事項: (2007)

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
著者:: Valletta, S, 等
出版事項: (2020)

Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function
著者:: Ryan J. Smith, 等
出版事項: (2023-01-01)

FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.
著者:: Pouget, C, 等
出版事項: (2014)

P1411: DUAL EPIGENETIC AND GENETIC EDITING OF PRIMARY HUMAN HAEMATOPOIETIC STEM AND PROGENITOR CELLS
著者:: E. Saunderson, 等
出版事項: (2022-06-01)

Epigenetic Regulation of Dental Pulp Stem Cell Fate
著者:: Dan Zhou, 等
出版事項: (2020-01-01)

The Haematopoietic Stem Cell Niche: New Insights into the Mechanisms Regulating Haematopoietic Stem Cell Behaviour
著者:: Andrew J. Lilly, 等
出版事項: (2011-01-01)

Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment
著者:: Xinxin Huang, 等
出版事項: (2018-07-01)

The Impact of Epigenetic Signatures on Amniotic Fluid Stem Cell Fate
著者:: Daniela Di Tizio, 等
出版事項: (2018-01-01)

Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell Fate Transitions
著者:: Li Sun, 等
出版事項: (2021-02-01)

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing
著者:: Simona Valletta, 等
出版事項: (2020-08-01)

Haematopoietic stem cell transplantation in Switzerland
著者:: Swiss Medical Weekly
出版事項: (2006-01-01)

In utero haematopoietic stem cell transplantation
著者:: C Troeger, 等
出版事項: (2006-08-01)

Dynamics of Haematopoietic Stem Cells Model
著者:: Julia Stoberova
出版事項: (2012-09-01)

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.
著者:: Di Genua, C, 等
出版事項: (2019)

S128: AML CONDITIONING OF THE BONE MARROW MICROENVIRONMENT THROUGH CCR1 LIGAND UP-REGULATION PROMOTES AML STEM CELL PROPAGATION AND IS MIMICKED BY AGEING
著者:: Xiying Ren, 等
出版事項: (2023-08-01)

Hematopoietic lineage diversification, simplified
著者:: Drissen, R, 等
出版事項: (2016)

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
著者:: Nygren, J, 等
出版事項: (2008)

P1403: ENDOMUCIN IS A MARKER OF QUIESCENT HAEMATOPOIETIC STEM CELLS WITH HIGH LONG-TERM ENGRAFTMENT CAPACITY
著者:: S. Engelhard, 等
出版事項: (2022-06-01)

Distinct myeloid progenitor differentiation pathways identified through single cell RNA sequencing
著者:: Drissen, R, 等
出版事項: (2016)

Reconstruction of Human AML Using Functionally and Immunophenotypically Defined Human Haematopoietic Stem and Progenitor Cells as Targeted Populations
著者:: Bernd Zeisig, 等
出版事項: (2021-12-01)

Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells
著者:: Hui Zhang, 等
出版事項: (2022-01-01)

JMJD3: a critical epigenetic regulator in stem cell fate
著者:: Yuanjie Ding, 等
出版事項: (2021-07-01)

Mesenchymal stem cells under epigenetic control – the role of epigenetic machinery in fate decision and functional properties
著者:: Alicja Walewska, 等
出版事項: (2023-11-01)

IN UTERO HAEMATOPOIETIC STEM CELL TRANSPLANTATION (IUHSCT)
著者:: Maria Concetta Renda, 等
出版事項: (2009-12-01)