Epigenetic programming defines haematopoietic stem cell fate restriction

Epigenetic programming defines haematopoietic stem cell fate restriction

Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is epigenetically but not transcriptionally primed in H...

Полное описание

Библиографические подробности
Главные авторы:	Meng, Y, de Teixeira Carrelha, J, Drissen, R, Ren, X, Zhang, B, Gambardella, A, Valletta, S, Thongjuea, S, Jacobsen, SE, Nerlov, C
Формат:	Journal article
Язык:	English
Опубликовано:	Springer Nature 2023

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