Epigenetic programming defines haematopoietic stem cell fate restriction
Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is epigenetically but not transcriptionally primed in H...
Автори: | Meng, Y, de Teixeira Carrelha, J, Drissen, R, Ren, X, Zhang, B, Gambardella, A, Valletta, S, Thongjuea, S, Jacobsen, SE, Nerlov, C |
---|---|
Формат: | Journal article |
Мова: | English |
Опубліковано: |
Springer Nature
2023
|
Схожі ресурси
Схожі ресурси
-
The road not taken: lineage bias and restriction of haematopoietic stem and progenitor cells
за авторством: de Teixeira Carrelha, J
Опубліковано: (2016) -
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells
за авторством: Amit Grover, та інші
Опубліковано: (2016-03-01) -
Hierarchically related lineage-restricted fates by multipotent hematopoietic stem cells
за авторством: Carrelha, C, та інші
Опубліковано: (2018) -
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy.
за авторством: Sanjuan-Pla, A, та інші
Опубліковано: (2013) -
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy
за авторством: Sanjuan-Pla, A, та інші
Опубліковано: (2013)