Epigenetic programming defines haematopoietic stem cell fate restriction

Haematopoietic stem cells (HSCs) are multipotent, but individual HSCs can show restricted lineage output in vivo. Currently, the molecular mechanisms and physiological role of HSC fate restriction remain unknown. Here we show that lymphoid fate is epigenetically but not transcriptionally primed in H...

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מידע ביבליוגרפי
Main Authors: Meng, Y, de Teixeira Carrelha, J, Drissen, R, Ren, X, Zhang, B, Gambardella, A, Valletta, S, Thongjuea, S, Jacobsen, SE, Nerlov, C
פורמט: Journal article
שפה:English
יצא לאור: Springer Nature 2023