Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews

Systematic reviews of clinical trials aim to include all relevant studies conducted on a particular topic and to provide an unbiased summary of their results, producing the best evidence about the benefits and harms of medical treatments. Relevant studies, however, may not provide the results for al...

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Main Authors: Kirkham, J, Altman, D, Chan, A, Gamble, C, Dwan, K, Williamson, P
Format: Journal article
Language:English
Published: BMJ Publishing Group 2018
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author Kirkham, J
Altman, D
Chan, A
Gamble, C
Dwan, K
Williamson, P
author_facet Kirkham, J
Altman, D
Chan, A
Gamble, C
Dwan, K
Williamson, P
author_sort Kirkham, J
collection OXFORD
description Systematic reviews of clinical trials aim to include all relevant studies conducted on a particular topic and to provide an unbiased summary of their results, producing the best evidence about the benefits and harms of medical treatments. Relevant studies, however, may not provide the results for all measured outcomes or may selectively report only some of the analyses undertaken, leading to unnecessary waste in the production and reporting of research, and potentially biasing the conclusions to systematic reviews. In this article, Kirkham and colleagues provide a methodological approach, with an example of how to identify missing outcome data and how to assess and adjust for outcome reporting bias in systematic reviews.
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spelling oxford-uuid:c7246c1a-ff98-4cc5-aa32-f4914fb9fb062022-03-27T06:42:56ZOutcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviewsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7246c1a-ff98-4cc5-aa32-f4914fb9fb06EnglishSymplectic Elements at OxfordBMJ Publishing Group2018Kirkham, JAltman, DChan, AGamble, CDwan, KWilliamson, PSystematic reviews of clinical trials aim to include all relevant studies conducted on a particular topic and to provide an unbiased summary of their results, producing the best evidence about the benefits and harms of medical treatments. Relevant studies, however, may not provide the results for all measured outcomes or may selectively report only some of the analyses undertaken, leading to unnecessary waste in the production and reporting of research, and potentially biasing the conclusions to systematic reviews. In this article, Kirkham and colleagues provide a methodological approach, with an example of how to identify missing outcome data and how to assess and adjust for outcome reporting bias in systematic reviews.
spellingShingle Kirkham, J
Altman, D
Chan, A
Gamble, C
Dwan, K
Williamson, P
Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews
title Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews
title_full Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews
title_fullStr Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews
title_full_unstemmed Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews
title_short Outcome reporting bias in trials: A methodological approach for assessment and adjustment in systematic reviews
title_sort outcome reporting bias in trials a methodological approach for assessment and adjustment in systematic reviews
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