DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.

DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer.

TAp63α, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. Remarkably, already undamaged oocytes express high levels of the protein, suggesting that TAp63α's activity is under tight control of an inhibitory mechanism. Biochemical studies have proposed tha...

書目詳細資料
Main Authors:	Deutsch, G, Zielonka, E, Coutandin, D, Weber, T, Schäfer, B, Hannewald, J, Luh, L, Durst, F, Ibrahim, M, Hoffmann, J, Niesen, F, Sentürk, A, Kunkel, H, Brutschy, B, Schleiff, E, Knapp, S, Acker-Palmer, A, Grez, M, McKeon, F, Dötsch, V
格式:	Journal article
語言:	English
出版:	2011

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