Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Baker, A, Huang, W, Wang, X, Jansen, M, Ma, X, Kim, J, Anderson, C, Wu, X, Pan, L, Su, N, Luo, Y, Domingo, E, Heide, T, Sottoriva, A, Lewis, A, Beggs, A, Wright, N, Rodriguez-Justo, M, Park, E, Tomlinson, I, Graham, T
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: Nature Publishing Group 2017

অনুরূপ উপাদানগুলি

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