Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Baker, A, Huang, W, Wang, X, Jansen, M, Ma, X, Kim, J, Anderson, C, Wu, X, Pan, L, Su, N, Luo, Y, Domingo, E, Heide, T, Sottoriva, A, Lewis, A, Beggs, A, Wright, N, Rodriguez-Justo, M, Park, E, Tomlinson, I, Graham, T
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Nature Publishing Group 2017

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Ижил төстэй зүйлс