Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Intra-tumor heterogeneity (ITH) is a major underlying cause of therapy resistance and disease recurrence, and is a read-out of tumor growth. Current genetic ITH analysis methods do not preserve spatial context and may not detect rare subclones. Here, we address these shortfalls by developing and val...

Ful tanımlama

Detaylı Bibliyografya
Asıl Yazarlar:	Baker, A, Huang, W, Wang, X, Jansen, M, Ma, X, Kim, J, Anderson, C, Wu, X, Pan, L, Su, N, Luo, Y, Domingo, E, Heide, T, Sottoriva, A, Lewis, A, Beggs, A, Wright, N, Rodriguez-Justo, M, Park, E, Tomlinson, I, Graham, T
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Nature Publishing Group 2017

Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.

Benzer Materyaller