Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications
Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative perfusion imaging of the brain using multi-timepoi...
| Autors principals: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Altres autors: | |
| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Wiley
2024
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| _version_ | 1826313620421607424 |
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| author | Woods, JG Achten, E Asllani, I Bolar, DS Dai, W Detre, JA Fan, AP Fernández‐Seara, MA Golay, X Günther, M Guo, J Hernandez‐Garcia, L Ho, M Juttukonda, MR Lu, H MacIntosh, BJ Madhuranthakam, AJ Mutsaerts, H Okell, TW Parkes, LM Pinter, N Pinto, J Qin, Q Smits, M Suzuki, Y Thomas, DL Van Osch, MJP Wang, DJJ Warnert, EAH Zaharchuk, G Zelaya, F Zhao, M Chappell, MA |
| author2 | the ISMRM Perfusion Study Group |
| author_facet | the ISMRM Perfusion Study Group Woods, JG Achten, E Asllani, I Bolar, DS Dai, W Detre, JA Fan, AP Fernández‐Seara, MA Golay, X Günther, M Guo, J Hernandez‐Garcia, L Ho, M Juttukonda, MR Lu, H MacIntosh, BJ Madhuranthakam, AJ Mutsaerts, H Okell, TW Parkes, LM Pinter, N Pinto, J Qin, Q Smits, M Suzuki, Y Thomas, DL Van Osch, MJP Wang, DJJ Warnert, EAH Zaharchuk, G Zelaya, F Zhao, M Chappell, MA |
| author_sort | Woods, JG |
| collection | OXFORD |
| description | Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative perfusion imaging of the brain using multi-timepoint arterial spin labeling (ASL), along with recommendations for its acquisition and quantification. A major benefit of acquiring ASL data with multiple label durations and/or post-labeling delays (PLDs) is being able to account for the effect of variable arterial transit time (ATT) on quantitative perfusion values and additionally visualize the spatial pattern of ATT itself, providing valuable clinical insights. Although multi-timepoint data can be acquired in the same scan time as single-PLD data with comparable perfusion measurement precision, its acquisition and postprocessing presents challenges beyond single-PLD ASL, impeding widespread adoption. Building upon the 2015 ASL consensus article, this work highlights the protocol distinctions specific to multi-timepoint ASL and provides robust recommendations for acquiring high-quality data. Additionally, we propose an extended quantification model based on the 2015 consensus model and discuss relevant postprocessing options to enhance the analysis of multi-timepoint ASL data. Furthermore, we review the potential clinical applications where multi-timepoint ASL is expected to offer significant benefits. This article is part of a series published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group, aiming to guide and inspire the advancement and utilization of ASL beyond the scope of the 2015 consensus article. |
| first_indexed | 2024-04-23T08:26:23Z |
| format | Journal article |
| id | oxford-uuid:c766ec9f-d8fc-4f1d-a812-a3db0b4034b0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:17:51Z |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:c766ec9f-d8fc-4f1d-a812-a3db0b4034b02024-07-24T09:12:33ZRecommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applicationsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c766ec9f-d8fc-4f1d-a812-a3db0b4034b0EnglishSymplectic ElementsWiley2024Woods, JGAchten, EAsllani, IBolar, DSDai, WDetre, JAFan, APFernández‐Seara, MAGolay, XGünther, MGuo, JHernandez‐Garcia, LHo, MJuttukonda, MRLu, HMacIntosh, BJMadhuranthakam, AJMutsaerts, HOkell, TWParkes, LMPinter, NPinto, JQin, QSmits, MSuzuki, YThomas, DLVan Osch, MJPWang, DJJWarnert, EAHZaharchuk, GZelaya, FZhao, MChappell, MAthe ISMRM Perfusion Study GroupAccurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision-making. This guidelines article provides a comprehensive overview of quantitative perfusion imaging of the brain using multi-timepoint arterial spin labeling (ASL), along with recommendations for its acquisition and quantification. A major benefit of acquiring ASL data with multiple label durations and/or post-labeling delays (PLDs) is being able to account for the effect of variable arterial transit time (ATT) on quantitative perfusion values and additionally visualize the spatial pattern of ATT itself, providing valuable clinical insights. Although multi-timepoint data can be acquired in the same scan time as single-PLD data with comparable perfusion measurement precision, its acquisition and postprocessing presents challenges beyond single-PLD ASL, impeding widespread adoption. Building upon the 2015 ASL consensus article, this work highlights the protocol distinctions specific to multi-timepoint ASL and provides robust recommendations for acquiring high-quality data. Additionally, we propose an extended quantification model based on the 2015 consensus model and discuss relevant postprocessing options to enhance the analysis of multi-timepoint ASL data. Furthermore, we review the potential clinical applications where multi-timepoint ASL is expected to offer significant benefits. This article is part of a series published by the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group, aiming to guide and inspire the advancement and utilization of ASL beyond the scope of the 2015 consensus article. |
| spellingShingle | Woods, JG Achten, E Asllani, I Bolar, DS Dai, W Detre, JA Fan, AP Fernández‐Seara, MA Golay, X Günther, M Guo, J Hernandez‐Garcia, L Ho, M Juttukonda, MR Lu, H MacIntosh, BJ Madhuranthakam, AJ Mutsaerts, H Okell, TW Parkes, LM Pinter, N Pinto, J Qin, Q Smits, M Suzuki, Y Thomas, DL Van Osch, MJP Wang, DJJ Warnert, EAH Zaharchuk, G Zelaya, F Zhao, M Chappell, MA Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications |
| title | Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications |
| title_full | Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications |
| title_fullStr | Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications |
| title_full_unstemmed | Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications |
| title_short | Recommendations for quantitative cerebral perfusion MRI using multi-timepoint arterial spin labeling: acquisition, quantification, and clinical applications |
| title_sort | recommendations for quantitative cerebral perfusion mri using multi timepoint arterial spin labeling acquisition quantification and clinical applications |
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