Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias.

BACKGROUND: Moderately elevated blood levels of homocysteine are weakly correlated with coronary heart disease (CHD) risk, but causality remains uncertain. When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR...

Descrición completa

Detalles Bibliográficos
Main Authors:	Clarke, R, Bennett, D, Parish, S, Verhoef, P, Dötsch-Klerk, M, Lathrop, M, Xu, P, Nordestgaard, BG, Holm, H, Hopewell, J, Saleheen, D, Tanaka, T, Anand, S, Chambers, J, Kleber, M, Ouwehand, W, Yamada, Y, Elbers, C, Peters, B, Stewart, A, Reilly, M, Thorand, B, Yusuf, S, Engert, J, Assimes, T, Kooner, J, Danesh, J, Watkins, H, Samani, N, Collins, R, Peto, R
Formato:	Journal article
Idioma:	English
Publicado:	2012

Títulos similares

Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies.
por: Den Heijer, M, et al.
Publicado: (2005)

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
por: Klerk, M, et al.
Publicado: (2002)

A Genome-Wide Association Study of Risk of Coronary Artery Disease in European and South Asian Populations
por: Hopewell, J, et al.
Publicado: (2010)

Association of MTHFR polymorphism, folic acid and vitamin B12 with serum homocysteine levels in pregnant women
por: Ana Bošković, et al.
Publicado: (2024-01-01)

Association of A1298C and C677T polymorphisms of MTHFR gene and homocysteine level in children with arterial hypertension
por: A.V. Luksha
Publicado: (2023-02-01)

Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies.
por: Danesh, J, et al.
Publicado: (1998)

Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.
por: Hopewell, J, et al.
Publicado: (2011)

MTHFR C677T polymorphism, homocysteine and B vitamins status in a sample of Chinese and Malay subjects in Universiti Putra Malaysia.
por: Choo, S. C., et al.
Publicado: (2011)

Association between Methylenetetrahydrofolate Reductase (MTHFR( and 5-Methyltetrahydrofolate- Homocysteine Methyltransferase Reductase (MTRR) Polymorphisms in Iraqi Patients with COVID-19
por: Sura F. Alsaffar, et al.
Publicado: (2024-07-01)

Homocysteine and vascular disease: Review of published results of the homocysteine-lowering trials
por: Clarke, R, et al.
Publicado: (2011)

Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials.
por: Clarke, R, et al.
Publicado: (2011)

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
por: Enciso, M, et al.
Publicado: (2016)

Association between MTHFR C677T Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
por: Zhi-Can Li, et al.
Publicado: (2024-01-01)

MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
por: Antoniades, C, et al.
Publicado: (2009)

Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12064 myocardial infarction survivors.
por: Bowman, L, et al.
Publicado: (2007)

No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.
por: Hopewell, J, et al.
Publicado: (2011)

Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
por: Al Jabr, Mohamed Talal Abd Alfattah
Publicado: (2011)

Association of MTHFR C677T, MTHFR A1298C polymorphism in relation to patients with autism in Thi-Qar Governorate
por: Roaa M. Nashee, et al.
Publicado: (2024-06-01)

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.
por: Hopewell, J, et al.
Publicado: (2013)

The Relationship between Homocysteine Levels, MTHFR C677T and A1298C Polymorphism, and Pregnancy Outcomes in Georgian Women with Polycystic Ovary Syndrome: A Case-Control Study
por: Elene Asanidze, et al.
Publicado: (2025-01-01)

Mthfr c677t genotype is not associated with ischaemic heart disease and stroke in a large prospective study in china
por: Bennett, D, et al.
Publicado: (2014)

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
por: Wensley, F, et al.
Publicado: (2011)

Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations.
por: Melse-Boonstra, A, et al.
Publicado: (2005)

Homocysteine, cancer and oncothrombosis
por: V. O. Bitsadze, et al.
Publicado: (2023-09-01)

Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study.
por: van Oort, F, et al.
Publicado: (2003)

Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study.
por: Prins, N, et al.
Publicado: (2002)

Gene of folate cycle MTHFR and nutrition
por: K. D. Ievleva, et al.
Publicado: (2016-05-01)

Homocysteine, the kidney, and vascular disease.
por: Haynes, R, et al.
Publicado: (2012)

Homocysteine, renal function, and risk of cardiovascular disease.
por: Clarke, R, et al.
Publicado: (2003)

Homocysteine, the kidney, and vascular disease Moderate differences in homocysteine concentrations do not cause vascular disease
por: Haynes, R, et al.
Publicado: (2012)

Environmental and genetic risk factors for myopathy in Chinese participants from HPS2-THRIVE
por: Hopewell, J, et al.
Publicado: (2012)

A genome-wide association study in Indian Asians identifies five novel genetic variants for type-2 diabetes
por: Sehmi, J, et al.
Publicado: (2011)

Homocysteine and cardiovascular disease. Overview.
por: Clarke, R
Publicado: (1998)

Homocysteine and coronary heart disease.
por: Clarke, R, et al.
Publicado: (2002)

Plasma fibrinogen and fibrinogen genotypes in 4685 cases of myocardial infarction and in 6002 controls: Test of causality by "Mendelian randomisation"
por: Youngman, L, et al.
Publicado: (2000)

Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'.
por: Keavney, B, et al.
Publicado: (2006)

MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults
por: Bennett, DA, et al.
Publicado: (2023)

A Patient with Combined CADASIL and MTHFR Homozygosity
por: Sidonie Ibrikji, et al.
Publicado: (2020-01-01)

Evaluation of the Role of Two SNPs in MTHFR Gene Polymorphisms (rs1801133) 677 C>T and (rs 1801131) 1298A>C with Homocysteine Level in Iraqi Patients with Chronic Kidney Disease
por: Saife AL-AHMER, et al.
Publicado: (2024-08-01)

Homocysteine and risk of cardiovascular disease and venous thrombosis
por: Clarke, R, et al.
Publicado: (2003)