Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.

The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a lar...

Full description

Bibliographic Details
Main Authors:	Day, C, Kiepiela, P, Leslie, A, van der Stok, M, Nair, K, Ismail, N, Honeyborne, I, Crawford, H, Coovadia, H, Goulder, P, Walker, B, Klenerman, P
Format:	Journal article
Language:	English
Published:	2007

Similar Items

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
by: Honeyborne, I, et al.
Published: (2007)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
by: Crawford, H, et al.
Published: (2007)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restrieted gag epitope in chronic human immunodeficiency virus type 1 infection (vol 81, pg 8346, 2007)
by: Crawford, H, et al.
Published: (2008)

HIV-1 Escape from an HLA-B*13-Restricted Gag Epitope Affects the Gag-Pol Frameshift Stem-loop and Reduces Viral Fitness
by: Prado, J, et al.
Published: (2008)

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
by: Ramduth, D, et al.
Published: (2009)

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
by: Ngumbela, K, et al.
Published: (2008)

Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
by: Honeyborne, I, et al.
Published: (2006)

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
by: Rolland, M, et al.
Published: (2008)

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.
by: Prado, J, et al.
Published: (2009)

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
by: Martinez-Picado, J, et al.
Published: (2006)

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
by: Frahm, N, et al.
Published: (2006)

Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
by: Matthews, P, et al.
Published: (2008)

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
by: Leslie, A, et al.
Published: (2006)

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. (vol 177, pg 4699, 2006)
by: Leslie, A, et al.
Published: (2006)

Erratum: Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype (Journal of Immunology (2006) 177 (4699-4708))
by: Leslie, A, et al.
Published: (2006)

Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays.
by: Goulder, P, et al.
Published: (2001)

Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
by: Thobakgale, C, et al.
Published: (2009)

Cytotoxic T lymphocytes and viral adaptation in HIV infection.
by: Goulder, P, et al.
Published: (2006)

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
by: Morgane Rolland, et al.
Published: (2008-01-01)

Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
by: Goulder, P, et al.
Published: (2000)

Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.
by: Frater, A, et al.
Published: (2007)

P09-18. Cw 0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
by: Honeyborne, I, et al.
Published: (2009)

Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
by: Honeyborne, I, et al.
Published: (2009)

P09-18. Cw*0303/0304 HIV specific CTL response toward GagYL9 select for HIV escape variants with low fitness that is compensated by intra-codon variation
by: Walker BD, et al.
Published: (2009-10-01)

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
by: Frahm, N, et al.
Published: (2005)

Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
by: Ramduth, D, et al.
Published: (2005)

HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
by: Rousseau, C, et al.
Published: (2008)

Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons.
by: Day, C, et al.
Published: (2008)

The Effect of Cumulative B*5703-Associated Escape Mutations on HIV-1 Replicative Capacity
by: Crawford, H, et al.
Published: (2008)

HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
by: Matthews, P, et al.
Published: (2009)

Analysis of the relationship between cytokine secretion and proliferative capacity in hepatitis C virus infection.
by: Semmo, N, et al.
Published: (2007)

Intrapatient escape in the A*0201-restricted epitope SLYNTVATL drives evolution of human immunodeficiency virus type 1 at the population level.
by: Edwards, C, et al.
Published: (2005)

Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.
by: Thobakgale, C, et al.
Published: (2007)

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
by: Rousseau, C, et al.
Published: (2007)

VARIATION IN T-CELL EPITOPES OF HIV-1 - SEQUENCES DETECTED IN VIRAL-RNA
by: Koppe, B, et al.
Published: (1995)

Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection.
by: Pillay, T, et al.
Published: (2005)

HLA Footprints on Human Immunodeficiency Virus Type 1 Are Associated with Interclade Polymorphisms and Intraclade Phylogenetic Clustering (vol 83, pg 4605, 2009)
by: Matthews, P, et al.
Published: (2011)

HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.
by: Kloverpris, H, et al.
Published: (2012)

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
by: Kiepiela, P, et al.
Published: (2007)

Revisiting the Influence of HLA-type, Frequency, HLA-supertype and Homozygosity on the Immune Control of HIV
by: Leslie, A, et al.
Published: (2008)