Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups.
OBJECTIVE: To assess the prevalence and characteristics of islet cell autoimmunity amongst women with gestational diabetes selected from South Asian and Afro-Caribbean as well as European populations. DESIGN: Cross-sectional retrospective survey of subject cohort. POPULATION: Three hundred and twent...
| Autores principales: | , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2001
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| _version_ | 1826296024276140032 |
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| author | Kousta, E Lawrence, N Anyaoku, V Johnston, D McCarthy, M |
| author_facet | Kousta, E Lawrence, N Anyaoku, V Johnston, D McCarthy, M |
| author_sort | Kousta, E |
| collection | OXFORD |
| description | OBJECTIVE: To assess the prevalence and characteristics of islet cell autoimmunity amongst women with gestational diabetes selected from South Asian and Afro-Caribbean as well as European populations. DESIGN: Cross-sectional retrospective survey of subject cohort. POPULATION: Three hundred and twenty-one women with a recent history of gestational diabetes (173 European, 86 South Asian and 62 Afro-Caribbean), a median (range) of 22 (1-150) months postpartum. RESULTS: Antibodies to Glutamic acid decarboxylase were found in 13 (4%) of these women. There was no difference in the prevalence of anti-glutamic acid decarboxylase positivity between the three ethnic groups (European 4.6%, South Asian 3.5%, Afro-Caribbean 3.2%). Anti-glutamic acid decarboxylase positive women were leaner than anti-glutamic acid decarboxylase negative women (body mass index, median (upper-lower quartile) 23.9 (22.5-26.7) vs 26.6 (23.4-30.5)kg/m2, P = 0.03, P = 0.049 allowing for ethnicity). There was no difference between glutamic acid decarboxylase-positive and glutamic acid decarboxylase-negative women for age, family history of diabetes, waist/hip ratio, prevalence of insulin treatment during pregnancy, postpartum glucose status, lipid profile and indices of insulin action and beta-cell function. CONCLUSIONS: Markers of islet cell autoimmunity are found as frequently in gestational diabetes women of South Asian and Afro-Caribbean origin, as they are in European subjects. Identification of future risk of type 1 diabetes is relevant to the planning of clinical management and intervention strategies in women with gestational diabetes of all major ethnic groups. |
| first_indexed | 2024-03-07T04:09:58Z |
| format | Journal article |
| id | oxford-uuid:c7824252-d1b3-4d00-aafd-badc6e6a82fc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:09:58Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:c7824252-d1b3-4d00-aafd-badc6e6a82fc2022-03-27T06:45:29ZPrevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7824252-d1b3-4d00-aafd-badc6e6a82fcEnglishSymplectic Elements at Oxford2001Kousta, ELawrence, NAnyaoku, VJohnston, DMcCarthy, MOBJECTIVE: To assess the prevalence and characteristics of islet cell autoimmunity amongst women with gestational diabetes selected from South Asian and Afro-Caribbean as well as European populations. DESIGN: Cross-sectional retrospective survey of subject cohort. POPULATION: Three hundred and twenty-one women with a recent history of gestational diabetes (173 European, 86 South Asian and 62 Afro-Caribbean), a median (range) of 22 (1-150) months postpartum. RESULTS: Antibodies to Glutamic acid decarboxylase were found in 13 (4%) of these women. There was no difference in the prevalence of anti-glutamic acid decarboxylase positivity between the three ethnic groups (European 4.6%, South Asian 3.5%, Afro-Caribbean 3.2%). Anti-glutamic acid decarboxylase positive women were leaner than anti-glutamic acid decarboxylase negative women (body mass index, median (upper-lower quartile) 23.9 (22.5-26.7) vs 26.6 (23.4-30.5)kg/m2, P = 0.03, P = 0.049 allowing for ethnicity). There was no difference between glutamic acid decarboxylase-positive and glutamic acid decarboxylase-negative women for age, family history of diabetes, waist/hip ratio, prevalence of insulin treatment during pregnancy, postpartum glucose status, lipid profile and indices of insulin action and beta-cell function. CONCLUSIONS: Markers of islet cell autoimmunity are found as frequently in gestational diabetes women of South Asian and Afro-Caribbean origin, as they are in European subjects. Identification of future risk of type 1 diabetes is relevant to the planning of clinical management and intervention strategies in women with gestational diabetes of all major ethnic groups. |
| spellingShingle | Kousta, E Lawrence, N Anyaoku, V Johnston, D McCarthy, M Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups. |
| title | Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups. |
| title_full | Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups. |
| title_fullStr | Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups. |
| title_full_unstemmed | Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups. |
| title_short | Prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups. |
| title_sort | prevalence and features of pancreatic islet cell autoimmunity in women with gestational diabetes from different ethnic groups |
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