Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study).
Observational studies suggest that diabetes is associated with a decreased risk of prostate cancer, but few are population based or have investigated associations with cancer stage or duration of diabetes. We report a case-control study nested within the population-based Prostate testing for cancer...
| Հիմնական հեղինակներ: | , , , , , , , |
|---|---|
| Ձևաչափ: | Journal article |
| Լեզու: | English |
| Հրապարակվել է: |
2011
|
| _version_ | 1826296025257607168 |
|---|---|
| author | Turner, E Lane, J Donovan, J Davis, M Metcalfe, C Neal, D Hamdy, F Martin, R |
| author_facet | Turner, E Lane, J Donovan, J Davis, M Metcalfe, C Neal, D Hamdy, F Martin, R |
| author_sort | Turner, E |
| collection | OXFORD |
| description | Observational studies suggest that diabetes is associated with a decreased risk of prostate cancer, but few are population based or have investigated associations with cancer stage or duration of diabetes. We report a case-control study nested within the population-based Prostate testing for cancer and Treatment (ProtecT) study ISRCTN20141297. Men aged 50-69 years based around 9 UK cities were invited for a prostate-specific antigen (PSA) test between June 2002 and November 2006. Amongst 55,215 PSA-tested men, 1,966 had histologically confirmed prostate cancer; of these, 1,422 (72.3%) completed the questionnaire and 1,291 (65.7%) had complete data for analysis. We randomly selected 6,479 age- (within 5 years) and general practice-matched controls. The prevalence of diabetes was 89/1,291 (6.9%) in cases and 555/6,479 (8.6%) in controls. Diabetes was associated with a reduced risk of prostate cancer (odds ratio = 0.78; 95% confidence interval: 0.61-0.99). There was weak evidence that the inverse association was greater for well- versus poorly differentiated cancers (p = 0.07). The magnitude of the inverse association did not change with increasing duration of diabetes (p for trend = 0.95). Diabetes is associated with a decreased risk of PSA-detected prostate cancer. These data add to the evidence of the association of diabetes with prostate cancer in the PSA era. |
| first_indexed | 2024-03-07T04:09:59Z |
| format | Journal article |
| id | oxford-uuid:c7832d04-e9ff-472b-aba3-be3b125b0dc0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:09:59Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:c7832d04-e9ff-472b-aba3-be3b125b0dc02022-03-27T06:45:31ZAssociation of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7832d04-e9ff-472b-aba3-be3b125b0dc0EnglishSymplectic Elements at Oxford2011Turner, ELane, JDonovan, JDavis, MMetcalfe, CNeal, DHamdy, FMartin, RObservational studies suggest that diabetes is associated with a decreased risk of prostate cancer, but few are population based or have investigated associations with cancer stage or duration of diabetes. We report a case-control study nested within the population-based Prostate testing for cancer and Treatment (ProtecT) study ISRCTN20141297. Men aged 50-69 years based around 9 UK cities were invited for a prostate-specific antigen (PSA) test between June 2002 and November 2006. Amongst 55,215 PSA-tested men, 1,966 had histologically confirmed prostate cancer; of these, 1,422 (72.3%) completed the questionnaire and 1,291 (65.7%) had complete data for analysis. We randomly selected 6,479 age- (within 5 years) and general practice-matched controls. The prevalence of diabetes was 89/1,291 (6.9%) in cases and 555/6,479 (8.6%) in controls. Diabetes was associated with a reduced risk of prostate cancer (odds ratio = 0.78; 95% confidence interval: 0.61-0.99). There was weak evidence that the inverse association was greater for well- versus poorly differentiated cancers (p = 0.07). The magnitude of the inverse association did not change with increasing duration of diabetes (p for trend = 0.95). Diabetes is associated with a decreased risk of PSA-detected prostate cancer. These data add to the evidence of the association of diabetes with prostate cancer in the PSA era. |
| spellingShingle | Turner, E Lane, J Donovan, J Davis, M Metcalfe, C Neal, D Hamdy, F Martin, R Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). |
| title | Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). |
| title_full | Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). |
| title_fullStr | Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). |
| title_full_unstemmed | Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). |
| title_short | Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study). |
| title_sort | association of diabetes mellitus with prostate cancer nested case control study prostate testing for cancer and treatment study |
| work_keys_str_mv | AT turnere associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT lanej associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT donovanj associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT davism associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT metcalfec associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT neald associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT hamdyf associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy AT martinr associationofdiabetesmellituswithprostatecancernestedcasecontrolstudyprostatetestingforcancerandtreatmentstudy |