NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins

NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins

The Neisseria meningitidis protein FrpC contains a self-processing module (SPM) undergoing autoproteolysis via an aspartic anhydride. Herein, we establish NeissLock, using a binding protein genetically fused to SPM. Upon calcium triggering of SPM, the anhydride at the C-terminus of the binding prote...

書誌詳細
主要な著者:	Scheu, A, Lim, S, Metzner, F, Mohammed, S, Howarth, M
フォーマット:	Journal article
言語:	English
出版事項:	Springer Nature 2021

類似資料

Harnessing bioreactivity for protein covalent probes against endogenous targets
著者:: Scheu, AHA
出版事項: (2021)

Utilising anhydride reactivity to target endogenous human proteins
著者:: Lim, SYT
出版事項: (2022)

Electrophilic affibodies forming covalent bonds to protein targets.
著者:: Holm, L, 等
出版事項: (2009)

Nanoteamwork: covalent protein assembly beyond duets towards protein ensembles and orchestras
著者:: Banerjee, A, 等
出版事項: (2017)

Insider information on successful covalent protein coupling with help from SpyBank
著者:: Keeble, A, 等
出版事項: (2019)

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
著者:: Atack, Thomas C, 等
出版事項: (2021)

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
著者:: Atack, Thomas C, 等
出版事項: (2021)

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins
著者:: Hemelaar, J, 等
出版事項: (2004)

Protein nanopores with covalently attached molecular adapters.
著者:: Wu, H, 等
出版事項: (2007)

Endogenous and chemical modifications of model proteins
著者:: Ressler, Valerie T.(Valerie Terynn)
出版事項: (2019)

Mode locking and entrainment of endogenous economic cycles
著者:: Haxholdt, Christian
出版事項: (2009)

The protein covalently linked to the 5' end of poliovirus RNA.
著者:: Ambros, Victor Robert
出版事項: (2009)

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin.
著者:: Zakeri, B, 等
出版事項: (2012)

Protein targeting /
著者:: 202319 Pugsley, Anthony P.
出版事項: (1989)

Maleic anhydride /
著者:: 231772 Trivedi, B. C., 等
出版事項: (1982)

Maleic anhydride
著者:: 8096 British Standards Institution
出版事項: (1964)

Phthalic anhydride
著者:: 8096 British Standards Institution
出版事項: (1964)

Targeted analysis of protein termini.
著者:: Dormeyer, W, 等
出版事項: (2007)

Evolution: endogenous viruses provide shortcuts in antiviral immunity
著者:: Katzourakis, A, 等
出版事項: (2016)

Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted
著者:: Deimel, LP, 等
出版事項: (2024)

Targeting and Manipulating Endogenous Transcriptional Condensates
著者:: Lee, Choongman
出版事項: (2024)

Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation
著者:: Cambria, Elena, 等
出版事項: (2015)

Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors
著者:: Kubánková, M, 等
出版事項: (2017)

Extending the scope of covalent peptide-protein conjugation: from purification to expanded nanoassembly
著者:: Khairil, INA
出版事項: (2019)

Targeting protein-protein interactions for cancer therapy
著者:: Anscombe, E
出版事項: (2012)

Targeting protein–protein interactions in the HIF system
著者:: Wilkins, S, 等
出版事項: (2016)

Protein targeting protocols /
著者:: Van Der Giezen, Mark
出版事項: (2007)

Acid anhydrides and asthma.
著者:: Taylor, A, 等
出版事項: (1987)

Specification for acetic anhydride
著者:: 8096 British Standards Institution

Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.
著者:: Dendooven, A, 等
出版事項: (2011)

Evidence for Restricted Reactivity of ADAMDEC1 with Protein Substrates and Endogenous Inhibitors.
著者:: Lund, J, 等
出版事項: (2015)

Regulation of myocyte contractility by endogenous NO: role of protein phosphatase 2A and protein kinase A-dependent signalling
著者:: Zhang, Y, 等
出版事項: (2008)

Investigating high-affinity non-covalent protein-ligand interaction via variants of streptavidin
著者:: Chivers, C
出版事項: (2011)

Single-molecule detection of nitrogen mustards by covalent reaction within a protein nanopore.
著者:: Wu, H, 等
出版事項: (2008)

Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher
著者:: Reddington, S, 等
出版事項: (2015)

An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells
著者:: Harikumar, Arigela, 等
出版事項: (2018)

Protein synthesis and targeting in yeast /
著者:: Brown, Alistair J., 等
出版事項: (1993)

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones
著者:: Truttmann, Matthias, 等
出版事項: (2016)

ATP gatekeeper of Plasmodium protein kinase may provide the opportunity to develop selective antimalarial drugs with multiple targets
著者:: Fauze Mahmud, 等
出版事項: (2020)

Parallel Automated Flow Synthesis of Covalent Protein Complexes That Can Inhibit MYC-Driven Transcription
著者:: Pomplun, Sebastian, 等
出版事項: (2022)