The FANCM family of DNA helicases/translocases.
FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of t...
| Main Author: | |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797094163590676480 |
|---|---|
| author | Whitby, M |
| author_facet | Whitby, M |
| author_sort | Whitby, M |
| collection | OXFORD |
| description | FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of the Fanconi Anemia Core Complex to sites of DNA damage, crossover avoidance during DNA double-strand break repair by homologous recombination, and the replicative bypass of DNA lesions by template switching. This review summarises our current understanding of the biochemical activities and biological functions of the FANCM family. |
| first_indexed | 2024-03-07T04:10:22Z |
| format | Journal article |
| id | oxford-uuid:c7a09147-7cb9-4234-b439-4046c4b55cd5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:10:22Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:c7a09147-7cb9-4234-b439-4046c4b55cd52022-03-27T06:46:21ZThe FANCM family of DNA helicases/translocases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7a09147-7cb9-4234-b439-4046c4b55cd5EnglishSymplectic Elements at Oxford2010Whitby, MFANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of the Fanconi Anemia Core Complex to sites of DNA damage, crossover avoidance during DNA double-strand break repair by homologous recombination, and the replicative bypass of DNA lesions by template switching. This review summarises our current understanding of the biochemical activities and biological functions of the FANCM family. |
| spellingShingle | Whitby, M The FANCM family of DNA helicases/translocases. |
| title | The FANCM family of DNA helicases/translocases. |
| title_full | The FANCM family of DNA helicases/translocases. |
| title_fullStr | The FANCM family of DNA helicases/translocases. |
| title_full_unstemmed | The FANCM family of DNA helicases/translocases. |
| title_short | The FANCM family of DNA helicases/translocases. |
| title_sort | fancm family of dna helicases translocases |
| work_keys_str_mv | AT whitbym thefancmfamilyofdnahelicasestranslocases AT whitbym fancmfamilyofdnahelicasestranslocases |