High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis.
BACKGROUND: Previous studies suggest that the antioxidants vitamins C and E may protect against development of knee osteoarthritis (OA). We examined the association of circulating levels of vitamin C and E with incident whole knee radiographic OA (WKROA). METHODS: We performed a nested case-control...
| Autors principals: | , , , , , , , , , |
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| Format: | Journal article |
| Idioma: | English |
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2014
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| _version_ | 1826296058262585344 |
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| author | Chaganti, R Tolstykh, I Javaid, M Neogi, T Torner, J Curtis, J Jacques, P Felson, D Lane, N Nevitt, M |
| author_facet | Chaganti, R Tolstykh, I Javaid, M Neogi, T Torner, J Curtis, J Jacques, P Felson, D Lane, N Nevitt, M |
| author_sort | Chaganti, R |
| collection | OXFORD |
| description | BACKGROUND: Previous studies suggest that the antioxidants vitamins C and E may protect against development of knee osteoarthritis (OA). We examined the association of circulating levels of vitamin C and E with incident whole knee radiographic OA (WKROA). METHODS: We performed a nested case-control study of incident WKROA in MOST, a cohort of 3,026 men and women aged 50-79 years with, or at high risk of, knee OA. Incident cases were knees without either tibiofemoral (TF) or patellofemoral (PF) OA at baseline that developed TF and/or PF OA by 30-month follow-up. Two control knees per case were selected from those eligible for WKROA that did not develop it. Vitamin C and E (alpha-tocopherol) assays were done on baseline supernatant plasma (PCA) and serum samples, respectively. We examined the association of gender-specific tertiles of vitamin C and E with incident WKROA using logistic regression with GEE, adjusting for age, gender, and obesity. RESULTS: Subjects without WKROA at baseline who were in the highest tertile of vitamin C had a higher incidence of WKROA [adjusted OR = 2.20 (95% CI: 1.12-4.33); P-value = 0.021], with similar results for the highest tertile of vitamin E [adjusted OR = 1.89 (1.02-3.50); P-value = 0.042], compared to those in the lowest tertiles. P-values for the trend of vitamin C and E tertiles and incident WKROA were 0.019 and 0.030, respectively. CONCLUSIONS: Higher levels of circulating vitamin C and E did not provide protection against incident radiographic knee OA, and may be associated with an increased risk of knee OA. |
| first_indexed | 2024-03-07T04:10:30Z |
| format | Journal article |
| id | oxford-uuid:c7aa787d-a19e-4f57-8604-e53e6a2ce1f0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:10:30Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:c7aa787d-a19e-4f57-8604-e53e6a2ce1f02022-03-27T06:46:55ZHigh plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7aa787d-a19e-4f57-8604-e53e6a2ce1f0EnglishSymplectic Elements at Oxford2014Chaganti, RTolstykh, IJavaid, MNeogi, TTorner, JCurtis, JJacques, PFelson, DLane, NNevitt, MBACKGROUND: Previous studies suggest that the antioxidants vitamins C and E may protect against development of knee osteoarthritis (OA). We examined the association of circulating levels of vitamin C and E with incident whole knee radiographic OA (WKROA). METHODS: We performed a nested case-control study of incident WKROA in MOST, a cohort of 3,026 men and women aged 50-79 years with, or at high risk of, knee OA. Incident cases were knees without either tibiofemoral (TF) or patellofemoral (PF) OA at baseline that developed TF and/or PF OA by 30-month follow-up. Two control knees per case were selected from those eligible for WKROA that did not develop it. Vitamin C and E (alpha-tocopherol) assays were done on baseline supernatant plasma (PCA) and serum samples, respectively. We examined the association of gender-specific tertiles of vitamin C and E with incident WKROA using logistic regression with GEE, adjusting for age, gender, and obesity. RESULTS: Subjects without WKROA at baseline who were in the highest tertile of vitamin C had a higher incidence of WKROA [adjusted OR = 2.20 (95% CI: 1.12-4.33); P-value = 0.021], with similar results for the highest tertile of vitamin E [adjusted OR = 1.89 (1.02-3.50); P-value = 0.042], compared to those in the lowest tertiles. P-values for the trend of vitamin C and E tertiles and incident WKROA were 0.019 and 0.030, respectively. CONCLUSIONS: Higher levels of circulating vitamin C and E did not provide protection against incident radiographic knee OA, and may be associated with an increased risk of knee OA. |
| spellingShingle | Chaganti, R Tolstykh, I Javaid, M Neogi, T Torner, J Curtis, J Jacques, P Felson, D Lane, N Nevitt, M High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. |
| title | High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. |
| title_full | High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. |
| title_fullStr | High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. |
| title_full_unstemmed | High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. |
| title_short | High plasma levels of vitamin C and E are associated with incident radiographic knee osteoarthritis. |
| title_sort | high plasma levels of vitamin c and e are associated with incident radiographic knee osteoarthritis |
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