The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2.

Ras activation as a consequence of antigen receptor (T-cell receptor; TCR) engagement on T lymphocytes is required for T-cell development, selection and function. Lymphocyte function-associated antigen-1 (LFA-1) mediates lymphocyte adhesion, stabilization of the immune synapse and bidirectional sign...

Full description

Bibliographic Details
Main Authors:	Mor, A, Campi, G, Du, G, Zheng, Y, Foster, D, Dustin, M, Philips, MR
Format:	Journal article
Language:	English
Published:	2007

Similar Items

Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.
by: Mor, A, et al.
Published: (2009)

Compartmentalized Ras signaling in lymphocytes
by: Philips MR
Published: (2009-02-01)

Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes
by: Thomas D. Manes, et al.
Published: (2022-10-01)

Costimulation: building an immunological synapse.
by: Dustin, M, et al.
Published: (1999)

A quantitative analysis of the contribution of costimulation to T cell activation by the T cell receptor and chimeric antigen receptors
by: Patel, AB
Published: (2023)

Ubiquitination role in TCR signaling and costimulation via GITR
by: Muller, J, et al.
Published: (2016)

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent
by: Diogo Gomes-Silva, et al.
Published: (2017-10-01)

Modeling costimulation.
Published: (2000)

On the role of receptor downregulation and costimulation in shaping the T cell response
by: Kruger, P
Published: (2018)

Phospholipase C isozymes as effectors of Ras superfamily GTPases
by: T. Kendall Harden, et al.
Published: (2009-01-01)

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair
by: Naresh Naik Ramavath, et al.
Published: (2021-12-01)

Outcomes of primary membranous nephropathy based on serum anti-phospholipase A2 receptor antibodies and glomerular phospholipase A2 receptor antigen status: a retrospective cohort study
by: Peihong Yin, et al.
Published: (2020-01-01)

An anti-phospholipase A2 receptor quantitative immunoassay and epitope analysis in membranous nephropathy reveals different antigenic domains of the receptor.
by: Astrid Behnert, et al.
Published: (2013-01-01)

Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma
by: Yudai Murayama, et al.
Published: (2021-12-01)

Costimulation and endogenous MHC ligands contribute to T cell recognition.
by: Wülfing, C, et al.
Published: (2002)

Role of Toll-like receptors in costimulating cytotoxic T cell responses.
by: Schwarz, K, et al.
Published: (2003)

Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation
by: Sara Zumerle, et al.
Published: (2017-11-01)

Biophysical mechanism for ras-nanocluster formation and signaling in plasma membrane.
by: Thomas Gurry, et al.
Published: (2009-07-01)

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.
by: Dustin, M, et al.
Published: (1997)

Anti-phospholipase A2 receptor antibodies in membranous nephropathy
by: Sangho Lee
Published: (2018-09-01)

CXCL12 Mediates Aberrant Costimulation of B Lymphocytes in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Immunodeficiency
by: Giuliana Roselli, et al.
Published: (2017-09-01)

New look at an old costimulator.
by: Linsley, P
Published: (2005)

Structural and mechanistic insights into ras association domains of phospholipase C epsilon.
by: Bunney, T, et al.
Published: (2006)

Costimulation blockade: current perspectives and implications for therapy.
by: Kinnear, G, et al.
Published: (2013)

Membranes as messengers in T cell adhesion signaling.
by: Dustin, M, et al.
Published: (2004)

A microfluidic platform reveals differential response of regulatory T cells to micropatterned costimulation arrays.
by: Lee, J, et al.
Published: (2015)

Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies
by: Ali Nayer, et al.
Published: (2013-10-01)

The significance of anti-phospholipase receptor antibodies in a patient with membranous nephropathy
by: Jayaprakash R Dasari, et al.
Published: (2020-01-01)

Young T cells age during a redirected anti-tumour attack: chimeric antigen receptor (CAR)-provided dual costimulation is half the battle.
by: Andreas A Hombach, et al.
Published: (2013-06-01)

A proteomic view at T cell costimulation.
by: Rudolf Lichtenfels, et al.
Published: (2012-01-01)

Costimulation Blockade in Vascularized Composite Allotransplantation
by: Dimitrios Giannis, et al.
Published: (2020-09-01)

Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling
by: Rajan Thakur, et al.
Published: (2016-11-01)

Actin foci facilitate activation of the phospholipase C-gamma in primary T lymphocytes via the WASP pathway
by: Kumari, S, et al.
Published: (2015)

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway
by: Dustin, M, et al.
Published: (2015)

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
by: Mor, A, et al.
Published: (2007)

Hypercoagulability and dyslipidemia in membranous nephropathy with anti-phospholipase A2 receptor antibodies
by: Michael Kitlinski, et al.
Published: (2025-12-01)

Autoantibodies against phospholipase A2 receptor in Korean patients with membranous nephropathy.
by: Yun Jung Oh, et al.
Published: (2013-01-01)

Thematic review series: Lipid Posttranslational Modifications CAAX modification and membrane targeting of Ras
by: Latasha P. Wright, et al.
Published: (2006-05-01)

The human T lymphocyte receptor complex for antigen and MHC.
by: Royer, H, et al.
Published: (1985)

Diacylglycerol generated in CHO cell plasma membrane by phospholipase C is used for triacylglycerol synthesis
by: R. Ariel Igal, et al.
Published: (2001-01-01)