Disrupting hypoxia-induced bicarbonate transport acidifies tumor cells and suppresses tumor growth
Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the hypothesis that impeding the reuptake of bicarbona...
| Auteurs principaux: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
American Association for Cancer Research
2016
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