Lethal malaria: Marchiafava and Bignami were right.

One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunc...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: White, N, Turner, G, Day, N, Dondorp, A
التنسيق: Journal article
اللغة:English
منشور في: 2013
الوصف
الملخص:One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.