Effective induction of high-titer antibodies by viral vector vaccines.

Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody res...

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Detalles Bibliográficos
Main Authors: Draper, S, Moore, A, Goodman, A, Long, C, Holder, A, Gilbert, S, Hill, F, Hill, A
Formato: Journal article
Idioma:English
Publicado: 2008
Descripción
Summary:Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.