Effective induction of high-titer antibodies by viral vector vaccines.
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody res...
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2008
|
| _version_ | 1826296128005472256 |
|---|---|
| author | Draper, S Moore, A Goodman, A Long, C Holder, A Gilbert, S Hill, F Hill, A |
| author_facet | Draper, S Moore, A Goodman, A Long, C Holder, A Gilbert, S Hill, F Hill, A |
| author_sort | Draper, S |
| collection | OXFORD |
| description | Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro. |
| first_indexed | 2024-03-07T04:11:34Z |
| format | Journal article |
| id | oxford-uuid:c7fe8d5e-f8fc-4bbe-a8cd-29f0abe1bd05 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:11:34Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:c7fe8d5e-f8fc-4bbe-a8cd-29f0abe1bd052022-03-27T06:49:09ZEffective induction of high-titer antibodies by viral vector vaccines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c7fe8d5e-f8fc-4bbe-a8cd-29f0abe1bd05EnglishSymplectic Elements at Oxford2008Draper, SMoore, AGoodman, ALong, CHolder, AGilbert, SHill, FHill, AProtein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro. |
| spellingShingle | Draper, S Moore, A Goodman, A Long, C Holder, A Gilbert, S Hill, F Hill, A Effective induction of high-titer antibodies by viral vector vaccines. |
| title | Effective induction of high-titer antibodies by viral vector vaccines. |
| title_full | Effective induction of high-titer antibodies by viral vector vaccines. |
| title_fullStr | Effective induction of high-titer antibodies by viral vector vaccines. |
| title_full_unstemmed | Effective induction of high-titer antibodies by viral vector vaccines. |
| title_short | Effective induction of high-titer antibodies by viral vector vaccines. |
| title_sort | effective induction of high titer antibodies by viral vector vaccines |
| work_keys_str_mv | AT drapers effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT moorea effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT goodmana effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT longc effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT holdera effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT gilberts effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT hillf effectiveinductionofhightiterantibodiesbyviralvectorvaccines AT hilla effectiveinductionofhightiterantibodiesbyviralvectorvaccines |