CAMPATH-IH in multiple sclerosis.

CAMPATH-IH in multiple sclerosis.

In a pilot study, seven patients with multiple sclerosis were treated with CAMPATH-IH which targets the CD52 antigen present on lymphocytes and monocytes. There was a substantial reduction in disease activity as measured by gadoliunium-enhancing lesions on MRI. Encouraged by this result a further se...

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Bibliografiske detaljer
Main Authors:	Moreau, T, Coles, A, Wing, M, Thorpe, J, Miller, D, Moseley, I, Issacs, J, Hale, G, Clayton, D, Scolding, N, Waldmann, H, Compston, A
Format:	Journal article
Sprog:	English
Udgivet:	1996

Lignende værker

Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis.
af: Moreau, T, et al.
Udgivet: (1994)

Inflammation, demyelination, and axonal degeneration: Three aspects of the pathogenesis of multiple sclerosis revealed by campath-1H treatment
af: Coles, A, et al.
Udgivet: (2003)

Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients.
af: Calne, R, et al.
Udgivet: (1999)

Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.
af: Moreau, T, et al.
Udgivet: (1996)

CAMPATH: from concept to clinic.
af: Waldmann, H, et al.
Udgivet: (2005)

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.
af: Wing, MG, et al.
Udgivet: (1996)

Specificity of monoclonal antibody Campath-1.
af: Hale, G, et al.
Udgivet: (1988)

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis.
af: Coles, A, et al.
Udgivet: (1999)

CAMPATH-1H in inflammatory arthritis.
af: Watts, R, et al.
Udgivet: (1993)

Availability of Campath-1 antibodies for bone marrow transplantation.
af: Hale, G, et al.
Udgivet: (1995)

CAMPATH-1 monoclonal antibodies in bone marrow transplantation.
af: Hale, G, et al.
Udgivet: (1994)

Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis.
af: Cox, A, et al.
Udgivet: (2005)

The CAMPATH-1 antigen (CDw52).
af: Hale, G, et al.
Udgivet: (1990)

T cell depletion with CAMPATH-1 in allogeneic bone marrow transplantation.
af: Hale, G, et al.
Udgivet: (1988)

Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G.
af: Williams, R, et al.
Udgivet: (2000)

Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.
af: Hale, G, et al.
Udgivet: (1996)

CAMPATH-1 antibodies in stem-cell transplantation.
af: Hale, G, et al.
Udgivet: (2001)

The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy.
af: Coles, A, et al.
Udgivet: (2006)

Campath-1H therapy in refractory ocular inflammatory disease.
af: Dick, A, et al.
Udgivet: (2000)

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.
af: Coles, A, et al.
Udgivet: (1999)

Leukaemic relapse after Campath 1-treated bone-marrow transplantation for leukaemia.
af: Waldmann, H, et al.
Udgivet: (1987)

TREATMENT OF RHEUMATOID-ARTHRITIS WITH HUMANIZED ANTILYMPHOCYTE ANTIBODY CAMPATH-1H
af: Watts, R, et al.
Udgivet: (1992)

Rat monoclonal antibodies for bone marrow transplantation--the CAMPATH series.
af: Waldmann, H, et al.
Udgivet: (1985)

Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?
af: Hale, G, et al.
Udgivet: (2002)

Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
af: Isaacs, J, et al.
Udgivet: (1996)

CAMPATH-1 MOAB IN THE TREATMENT OF REFRACTORY AUTOIMMUNE THROMBOCYTOPENIC PURPURA (ATP)
af: Lim, S, et al.
Udgivet: (1993)

Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience.
af: Novitzky, N, et al.
Udgivet: (2004)

Sustained remission of severe resistant autoimmune neutropenia with Campath-1H.
af: Killick, S, et al.
Udgivet: (1997)

CAMPATH-1 FOLLOWING RENAL-TRANSPLANTATION - A RANDOMIZED TRIAL
af: Friend, P, et al.
Udgivet: (1988)

In vivo 'purging' of residual disease in CLL with Campath-1H.
af: Dyer, M, et al.
Udgivet: (1997)

Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
af: Xia, M, et al.
Udgivet: (1993)

EFFECTS OF MONOCLONAL-ANTIBODIES OF THE CAMPATH SERIES INVIVO - REQUIREMENTS FOR EFFECTIVE ANTIBODY THERAPY
af: Dyer, M, et al.
Udgivet: (1988)

CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura.
af: Lim, S, et al.
Udgivet: (1993)

ISOTYPE VARIANTS OF CAMPATH-1 ANTIBODY - REQUIREMENTS FOR EFFECTIVE ANTIBODY ACTION INVIVO
af: Dyer, M, et al.
Udgivet: (1989)

The effect of treatment with Campath-1H in patients with autoimmune cytopenias.
af: Willis, F, et al.
Udgivet: (2001)

Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.
af: Greenwood, J, et al.
Udgivet: (1994)

COMPLEMENT LYSIS MEDIATED BY ENGINEERED MULTIPLE-DOMAIN FORMS OF THE THERAPEUTIC ANTIBODY CAMPATH-1H
af: Greenwood, J, et al.
Udgivet: (1994)

RAT MONOCLONAL-ANTIBODIES FOR BONE-MARROW TRANSPLANTATION (BMT) - THE CAMPATH SERIES
af: Waldmann, H, et al.
Udgivet: (1985)

A personal history of the CAMPATH-1H antibody.
af: Waldmann, H
Udgivet: (2002)

Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.
af: Isaacs, J, et al.
Udgivet: (1995)