Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized to many promoters and enhancers and deposits the m...

Podrobná bibliografie
Hlavní autoři:	Xu, W, He, C, Kaye, EG, Li, J, Mu, M, Nelson, GM, Dong, L, Wang, J, Wu, F, Shi, YG, Adelman, K, Lan, F, Shi, Y, Shen, H
Médium:	Journal article
Jazyk:	English
Vydáno:	Cell Press 2022

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