TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.

AIMS/HYPOTHESIS: The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association analysis. We investigated the role of two common variants in TCF7L2 in a large case-control study recruited from the T...

书目详细资料
Main Authors:	Kimber, C, Doney, A, Pearson, E, McCarthy, M, Hattersley, A, Leese, G, Morris, A, Palmer, C
格式:	Journal article
语言:	English
出版:	2007

相似书籍

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
由: Pearson, E, et al.
出版: (2007)

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
由: Zhou, K, et al.
出版: (2009)

Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.
由: Zhou, K, et al.
出版: (2010)

Pharmacogenetics in Type 2 diabetes: variation in TCF7L2 influences response to sulphonylureas
由: Pearson, E, et al.
出版: (2007)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with Type 2 diabetes: A Go-DARTS study
由: Donnelly, L, et al.
出版: (2011)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.
由: Donnelly, L, et al.
出版: (2011)

Metformin Pharmacogenetics and SLC2A2: Genome-Wide Association Study and 2-stage replication in GoDARTS and UKPDS
由: Zhou, K, et al.
出版: (2013)

Retinal vascular measures from diabetes retinal screening photographs and risk of incident dementia in type 2 diabetes: A GoDARTS study
由: Alexander S. F. Doney, et al.
出版: (2022-08-01)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
由: Groves, C, et al.
出版: (2006)

TCF7L2 and diabetes: a tale of two tissues, and of two species.
由: McCarthy, M, et al.
出版: (2013)

Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
由: Timpson, N, et al.
出版: (2009)

TCF7L2: the biggest story in diabetes genetics since HLA?
由: Zeggini, E, et al.
出版: (2007)

Novel TCF4:TCF12 heterodimer inhibits glioblastoma growth
由: Svetlana A. Mikheeva, et al.
出版: (2024-03-01)

Identification of additional type 2 diabetes susceptibility loci through large-scale replication using "Metabochip": early result
由: Prokopenko, I, et al.
出版: (2010)

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility
由: Jafar-Mohammadi, B, et al.
出版: (2011)

A role for coding functional variants in HNF4A in type 2 diabetes susceptibility.
由: Jafar-Mohammadi, B, et al.
出版: (2011)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
由: Freathy, R, et al.
出版: (2007)

TCF7L2 correlation in both insulin secretion and postprandial insulin sensitivity
由: Mari Cassol Ferreira, et al.
出版: (2018-04-01)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
由: Groves, C, et al.
出版: (2006)

Objets d'art, oeuvres d'art
由: Muriel Verbeeck-Boutin
出版: (2008-10-01)

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
由: Freathy, R, et al.
出版: (2007)

Comparing low-dose (DART) and enhanced low-dose dexamethasone regimens in preterm infants with bronchopulmonary dysplasia
由: Heba Mohamed Al-taweel, et al.
出版: (2023-10-01)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
由: Owen, K, et al.
出版: (2006)

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
由: Palmer, C, et al.
出版: (2012)

Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon
由: Mary Jo Talley, et al.
出版: (2023-09-01)

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
由: Lango, H, et al.
出版: (2008)

TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation
由: Guotao Yu, et al.
出版: (2020-01-01)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
由: Jafar-Mohammadi, B, et al.
出版: (2009)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
由: Jafar-Mohammadi, B, et al.
出版: (2009)

Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians
由: L.F. Franco, et al.
出版: (2011-03-01)

Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians
由: L.F. Franco, et al.
出版: (2011-03-01)

Fine-scale mapping of type 2 diabetes susceptibility loci by imputation and conditional analysis
由: Wiltshire, S, et al.
出版: (2010)

Lucy Observations of the DART Impact Event
由: H. A. Weaver, et al.
出版: (2024-01-01)

Type 2 diabetes susceptibility gene TCF7L2 and its role in beta-cell function.
由: Gloyn, A, et al.
出版: (2009)

What makes a good genetic association study?
由: Hattersley, A, et al.
出版: (2005)

Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes.
由: McCarthy, M, et al.
出版: (2008)

What makes a good genetic association study?
由: Hattersley, A, et al.
出版: (2005)

TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophy
由: Sanjib Saha, et al.
出版: (2024-11-01)

Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes
由: Jafar-Mohammadi, B, et al.
出版: (2010)

DART and laboratory monitoring of HIV treatment Reply
由: Walker, A, et al.
出版: (2010)