Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice
<p><strong>Background</strong> The mammalian gut microbiota influences a wide array of phenotypes which are relevant to fitness, yet knowledge about the transmission routes by which gut microbes colonise hosts in natural populations remains limited. Here, we use an intensively stud...
| Main Authors: | , , , , |
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| פורמט: | Journal article |
| שפה: | English |
| יצא לאור: |
BioMed Central
2023
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| _version_ | 1826310847675236352 |
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| author | Wanelik, KM Raulo, A Troitsky, T Husby, A Knowles, SCL |
| author_facet | Wanelik, KM Raulo, A Troitsky, T Husby, A Knowles, SCL |
| author_sort | Wanelik, KM |
| collection | OXFORD |
| description | <p><strong>Background</strong> The mammalian gut microbiota influences a wide array of phenotypes which are relevant to fitness, yet knowledge about the transmission routes by which gut microbes colonise hosts in natural populations remains limited. Here, we use an intensively studied wild population of wood mice (<i>Apodemus sylvaticus</i>) to examine how vertical (maternal) and horizontal (social) transmission routes influence gut microbiota composition throughout life.</p>
<p><strong>Results</strong> We identify independent signals of maternal transmission (sharing of taxa between a mother and her offspring) and social transmission (sharing of taxa predicted by the social network), whose relative magnitudes shift as hosts age. In early life, gut microbiota composition is predicted by both maternal and social relationships, but by adulthood the impact of maternal transmission becomes undetectable, leaving only a signal of social transmission. By exploring which taxa drive the maternal transmission signal, we identify a candidate maternally-transmitted bacterial family in wood mice, the <i>Muribaculaceae</i>.</p>
<p><strong>Conclusion</strong> Overall, our findings point to an ontogenetically shifting transmission landscape in wild mice, with a mother’s influence on microbiota composition waning as offspring age, while the relative impact of social contacts grows.</p> |
| first_indexed | 2024-03-07T07:59:32Z |
| format | Journal article |
| id | oxford-uuid:c83790a2-239d-4997-a07e-80d08343b2a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:59:32Z |
| publishDate | 2023 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:c83790a2-239d-4997-a07e-80d08343b2a62023-09-11T11:29:54ZMaternal transmission gives way to social transmission during gut microbiota assembly in wild miceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c83790a2-239d-4997-a07e-80d08343b2a6EnglishSymplectic ElementsBioMed Central2023Wanelik, KMRaulo, ATroitsky, THusby, AKnowles, SCL<p><strong>Background</strong> The mammalian gut microbiota influences a wide array of phenotypes which are relevant to fitness, yet knowledge about the transmission routes by which gut microbes colonise hosts in natural populations remains limited. Here, we use an intensively studied wild population of wood mice (<i>Apodemus sylvaticus</i>) to examine how vertical (maternal) and horizontal (social) transmission routes influence gut microbiota composition throughout life.</p> <p><strong>Results</strong> We identify independent signals of maternal transmission (sharing of taxa between a mother and her offspring) and social transmission (sharing of taxa predicted by the social network), whose relative magnitudes shift as hosts age. In early life, gut microbiota composition is predicted by both maternal and social relationships, but by adulthood the impact of maternal transmission becomes undetectable, leaving only a signal of social transmission. By exploring which taxa drive the maternal transmission signal, we identify a candidate maternally-transmitted bacterial family in wood mice, the <i>Muribaculaceae</i>.</p> <p><strong>Conclusion</strong> Overall, our findings point to an ontogenetically shifting transmission landscape in wild mice, with a mother’s influence on microbiota composition waning as offspring age, while the relative impact of social contacts grows.</p> |
| spellingShingle | Wanelik, KM Raulo, A Troitsky, T Husby, A Knowles, SCL Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| title | Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| title_full | Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| title_fullStr | Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| title_full_unstemmed | Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| title_short | Maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| title_sort | maternal transmission gives way to social transmission during gut microbiota assembly in wild mice |
| work_keys_str_mv | AT wanelikkm maternaltransmissiongiveswaytosocialtransmissionduringgutmicrobiotaassemblyinwildmice AT rauloa maternaltransmissiongiveswaytosocialtransmissionduringgutmicrobiotaassemblyinwildmice AT troitskyt maternaltransmissiongiveswaytosocialtransmissionduringgutmicrobiotaassemblyinwildmice AT husbya maternaltransmissiongiveswaytosocialtransmissionduringgutmicrobiotaassemblyinwildmice AT knowlesscl maternaltransmissiongiveswaytosocialtransmissionduringgutmicrobiotaassemblyinwildmice |