Structure and function of membrane proteins important in synaptic signalling

Structure and function of membrane proteins important in synaptic signalling

<p>Membrane proteins are integral to synaptic signalling. This DPhil project explores the structures and functions of the muscle-type nicotinic acetylcholine receptor (AChR), a ligand-gated ion channel, and the SLC1 family of glutamate transporters.</p> <p>AChR is a pentameric lig...

ver descrição completa

Detalhes bibliográficos
Autor principal:	Li, A
Outros Autores:	Dong, Y
Formato:	Thesis
Idioma:	English
Publicado em:	2024
Assuntos:	Protein-protein interactions Biochemistry Ion channels structural biology Neurosciences Membrane proteins cryo-EM Protein complexes

Registos relacionados

An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub6
Por: Xiang Chen, et al.
Publicado em: (2021-03-01)

Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED)
Por: Michael W. Martynowycz, et al.
Publicado em: (2021-09-01)

Purification of full-length recombinant human huntingtin proteins with allelic series of polyglutamine lengths
Por: Hyeongju Kim, et al.
Publicado em: (2021-12-01)

To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a Say
Por: Gui-Lan Chen, et al.
Publicado em: (2023-07-01)

Expression and purification of phage T7 ejection proteins for cryo-EM analysis
Por: Nicholas A. Swanson, et al.
Publicado em: (2021-12-01)

Cryo-EM analysis of Ebola virus nucleocapsid-like assembly
Por: Yan Wang, et al.
Publicado em: (2022-03-01)

Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells
Por: Guimei Yu, et al.
Publicado em: (2022-06-01)

New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility
Por: Robbins Puthenveetil, et al.
Publicado em: (2022-02-01)

Protocol for preparing SUV420H1 in complex with the nucleosome containing H2A.Z and H4K20Ecx for structure determination
Por: Li Huang, et al.
Publicado em: (2024-09-01)

Cryo-EM Grid Preparation of Membrane Protein Samples for Single Particle Analysis
Por: Germán G. Sgro, et al.
Publicado em: (2018-07-01)

A protocol for capturing RNA-sensing innate immune receptors in multiple conformations by single-particle cryo-EM
Por: Wenshuai Wang, et al.
Publicado em: (2023-06-01)

Purification and cryoelectron microscopy structure determination of human V-ATPase
Por: Longfei Wang, et al.
Publicado em: (2021-03-01)

Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A
Por: Christopher M Hoel, et al.
Publicado em: (2022-11-01)

Detergents and alternatives in cryo-EM studies of membrane proteins
Por: Li Shuo
Publicado em: (2022-07-01)

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells
Por: Yao Rong, et al.
Publicado em: (2021-08-01)

Pain or gain?
Por: Valeria Kalienkova
Publicado em: (2021-09-01)

Assembly and purification of AvrSr35-induced Sr35 resistosome and determination of its structure by cryo-EM
Por: Meng-Xi Liu, et al.
Publicado em: (2022-12-01)

Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction
Por: Lan Wang, et al.
Publicado em: (2020-01-01)

HDX-guided EPR spectroscopy to interrogate membrane protein dynamics
Por: Benjamin J. Lane, et al.
Publicado em: (2022-09-01)

Generating tools for the characterisation of cell surface proteins
Por: Kokolaki, M
Publicado em: (2023)

Structural and functional characterisation of the fungal plasma membrane proton pump, Pma1, and related P-Type ATPases
Por: Geurts, MMG
Publicado em: (2022)

Capturing the signal
Por: Jee-Young Mock, et al.
Publicado em: (2015-07-01)

Protocol for the isolation and proteomic analysis of pathological tau-seeds
Por: Pablo Martinez, et al.
Publicado em: (2024-09-01)

Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue
Por: Iva Stojkovska, et al.
Publicado em: (2021-03-01)

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin
Por: Chanhyung Bae, et al.
Publicado em: (2016-02-01)

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
Por: Lan Wang, et al.
Publicado em: (2022-05-01)

Structural analysis of Wnt signalling pathways
Por: Ruza, RR
Publicado em: (2021)

CryoEM Reveals the Complexity and Diversity of ATP Synthases
Por: Gautier M. Courbon, et al.
Publicado em: (2022-06-01)

Structure of the connexin-43 gap junction channel in a putative closed state
Por: Chao Qi, et al.
Publicado em: (2023-08-01)

Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment
Por: Bankala Krishnarjuna, et al.
Publicado em: (2022-08-01)

Structural overview of the translocase of the mitochondrial outer membrane complex
Por: Yuhei Araiso, et al.
Publicado em: (2022-06-01)

Protein denaturation at the air-water interface and how to prevent it
Por: Edoardo D'Imprima, et al.
Publicado em: (2019-04-01)

A Structural View on the Maturation of Lanthipeptides
Por: Marcel Lagedroste, et al.
Publicado em: (2020-06-01)

Editorial: Structural Studies of Protein Complexes in Signaling Pathways
Por: Filippo Prischi, et al.
Publicado em: (2021-04-01)

Editorial: Recent advances in molecular properties of DNA-protein interactions, chromatin and their biological roles
Por: Xiangyan Shi, et al.
Publicado em: (2023-03-01)

The Coronavirus E Protein: Assembly and Beyond
Por: Travis R. Ruch, et al.
Publicado em: (2012-03-01)

Biophysical analysis of membrane proteins : investigating structure and function /
Por: Pebay-Peyroula, Eva
Publicado em: (2008)

Editorial: Structural dynamics of membrane proteins, Volume II
Por: H. Raghuraman, et al.
Publicado em: (2022-10-01)

Structure–Function Diversity of Calcium-Binding Proteins (CaBPs): Key Roles in Cell Signalling and Disease
Por: Vanessa S. Morris, et al.
Publicado em: (2025-01-01)

Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity
Por: Edward M Germany, et al.
Publicado em: (2024-01-01)