Structure and function of membrane proteins important in synaptic signalling

Structure and function of membrane proteins important in synaptic signalling

<p>Membrane proteins are integral to synaptic signalling. This DPhil project explores the structures and functions of the muscle-type nicotinic acetylcholine receptor (AChR), a ligand-gated ion channel, and the SLC1 family of glutamate transporters.</p> <p>AChR is a pentameric lig...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Li, A
Andre forfattere:	Dong, Y
Format:	Thesis
Sprog:	English
Udgivet:	2024
Fag:	Protein-protein interactions Biochemistry Ion channels structural biology Neurosciences Membrane proteins cryo-EM Protein complexes

Lignende værker

An optimized protocol for acquiring and processing cryo-EM data of human 26S proteasome with M1-Ub6
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Protocol for the use of focused ion-beam milling to prepare crystalline lamellae for microcrystal electron diffraction (MicroED)
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Purification of full-length recombinant human huntingtin proteins with allelic series of polyglutamine lengths
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To Be or Not to Be an Ion Channel: Cryo-EM Structures Have a Say
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Expression and purification of phage T7 ejection proteins for cryo-EM analysis
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Cryo-EM analysis of Ebola virus nucleocapsid-like assembly
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Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells
af: Guimei Yu, et al.
Udgivet: (2022-06-01)

New Horizons in Structural Biology of Membrane Proteins: Experimental Evaluation of the Role of Conformational Dynamics and Intrinsic Flexibility
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Udgivet: (2022-02-01)

Protocol for preparing SUV420H1 in complex with the nucleosome containing H2A.Z and H4K20Ecx for structure determination
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Cryo-EM Grid Preparation of Membrane Protein Samples for Single Particle Analysis
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Udgivet: (2018-07-01)

A protocol for capturing RNA-sensing innate immune receptors in multiple conformations by single-particle cryo-EM
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Udgivet: (2023-06-01)

Purification and cryoelectron microscopy structure determination of human V-ATPase
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Udgivet: (2021-03-01)

Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A
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Udgivet: (2022-11-01)

Detergents and alternatives in cryo-EM studies of membrane proteins
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Udgivet: (2022-07-01)

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells
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Assembly and purification of AvrSr35-induced Sr35 resistosome and determination of its structure by cryo-EM
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Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction
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HDX-guided EPR spectroscopy to interrogate membrane protein dynamics
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Generating tools for the characterisation of cell surface proteins
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Structural and functional characterisation of the fungal plasma membrane proton pump, Pma1, and related P-Type ATPases
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Udgivet: (2022)

Capturing the signal
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Protocol for the isolation and proteomic analysis of pathological tau-seeds
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Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue
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Udgivet: (2021-03-01)

Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin
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Udgivet: (2016-02-01)

Conserved structural elements specialize ATAD1 as a membrane protein extraction machine
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Udgivet: (2022-05-01)

Structural analysis of Wnt signalling pathways
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Udgivet: (2021)

CryoEM Reveals the Complexity and Diversity of ATP Synthases
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Udgivet: (2022-06-01)

Structure of the connexin-43 gap junction channel in a putative closed state
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Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment
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Structural overview of the translocase of the mitochondrial outer membrane complex
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Protein denaturation at the air-water interface and how to prevent it
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Udgivet: (2019-04-01)

A Structural View on the Maturation of Lanthipeptides
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Udgivet: (2020-06-01)

Editorial: Structural Studies of Protein Complexes in Signaling Pathways
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Editorial: Recent advances in molecular properties of DNA-protein interactions, chromatin and their biological roles
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The Coronavirus E Protein: Assembly and Beyond
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Udgivet: (2012-03-01)

Biophysical analysis of membrane proteins : investigating structure and function /
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Udgivet: (2008)

Editorial: Structural dynamics of membrane proteins, Volume II
af: H. Raghuraman, et al.
Udgivet: (2022-10-01)

Structure–Function Diversity of Calcium-Binding Proteins (CaBPs): Key Roles in Cell Signalling and Disease
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Udgivet: (2025-01-01)

Dual recognition of multiple signals in bacterial outer membrane proteins enhances assembly and maintains membrane integrity
af: Edward M Germany, et al.
Udgivet: (2024-01-01)