2 ALEXINES [3-HYDROXYMETHYL-1,2,7-TRIHYDROXYPYRROLIZIDINES] FROM CASTANOSPERMUM-AUSTRALE

Two new alexines have been isolated from Castanospermum australe. The structure of 1,7a-diepialexine was firmly established by X-ray crystallographic analysis of the corresponding 1,7-isopropylidene derivative. The structure of the second new alexine was tentatively assigned as 7,7a-diepialexine or...

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Bibliographic Details
Main Authors: Nash, R, Fellows, L, Dring, J, Fleet, G, Girdhar, A, Ramsden, N, Peach, J, Hegarty, M, Scofield, A
Format: Journal article
Language:English
Published: 1990
Description
Summary:Two new alexines have been isolated from Castanospermum australe. The structure of 1,7a-diepialexine was firmly established by X-ray crystallographic analysis of the corresponding 1,7-isopropylidene derivative. The structure of the second new alexine was tentatively assigned as 7,7a-diepialexine or its enantiomer. The abilities of naturally occurring alexines to inhibit mouse gut disaccharidase and fungal glucan 1,4-α-glucosidase are compared. © 1990.