BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration
<p><strong>Background and aims:</strong> In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimenta...
Prif Awduron: | Koppens, MAJ, Davis, H, Valbuena, GN, Mulholland, E, Simmons, A, Nasreddin, N, East, J, Friedrich, M, Antanaviciute, A, Leedham, S |
---|---|
Fformat: | Journal article |
Iaith: | English |
Cyhoeddwyd: |
Elsevier
2021
|
Eitemau Tebyg
-
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.
gan: Jaeger, E, et al.
Cyhoeddwyd: (2012) -
Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
gan: Jaeger, E, et al.
Cyhoeddwyd: (2012) -
Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism
gan: Gooding, S, et al.
Cyhoeddwyd: (2020) -
Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
gan: Davis, H, et al.
Cyhoeddwyd: (2015) -
Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer.
gan: Tomlinson, I, et al.
Cyhoeddwyd: (2011)