The role of immunity in mosquito-induced attenuation of malaria virulence.
A recent study found that mosquito-transmitted (MT) lines of rodent malaria parasites elicit a more effective immune response than non-transmitted lines maintained by serial blood passage (non-MT), thereby causing lower parasite densities in the blood and less pathology to the host. The authors attr...
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797094379499814912 |
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| author | Mackinnon, M |
| author_facet | Mackinnon, M |
| author_sort | Mackinnon, M |
| collection | OXFORD |
| description | A recent study found that mosquito-transmitted (MT) lines of rodent malaria parasites elicit a more effective immune response than non-transmitted lines maintained by serial blood passage (non-MT), thereby causing lower parasite densities in the blood and less pathology to the host. The authors attribute these changes to higher diversity in expression of antigen-encoding genes in MT cf. non-MT lines. Alternative explanations that are equally parsimonious with these new data, and results from previous studies, suggest that this conclusion may be premature. |
| first_indexed | 2024-03-07T04:13:18Z |
| format | Journal article |
| id | oxford-uuid:c88e684c-30da-4c62-bfec-13c7080fec6a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:13:18Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:c88e684c-30da-4c62-bfec-13c7080fec6a2022-03-27T06:53:01ZThe role of immunity in mosquito-induced attenuation of malaria virulence.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c88e684c-30da-4c62-bfec-13c7080fec6aEnglishSymplectic Elements at Oxford2014Mackinnon, MA recent study found that mosquito-transmitted (MT) lines of rodent malaria parasites elicit a more effective immune response than non-transmitted lines maintained by serial blood passage (non-MT), thereby causing lower parasite densities in the blood and less pathology to the host. The authors attribute these changes to higher diversity in expression of antigen-encoding genes in MT cf. non-MT lines. Alternative explanations that are equally parsimonious with these new data, and results from previous studies, suggest that this conclusion may be premature. |
| spellingShingle | Mackinnon, M The role of immunity in mosquito-induced attenuation of malaria virulence. |
| title | The role of immunity in mosquito-induced attenuation of malaria virulence. |
| title_full | The role of immunity in mosquito-induced attenuation of malaria virulence. |
| title_fullStr | The role of immunity in mosquito-induced attenuation of malaria virulence. |
| title_full_unstemmed | The role of immunity in mosquito-induced attenuation of malaria virulence. |
| title_short | The role of immunity in mosquito-induced attenuation of malaria virulence. |
| title_sort | role of immunity in mosquito induced attenuation of malaria virulence |
| work_keys_str_mv | AT mackinnonm theroleofimmunityinmosquitoinducedattenuationofmalariavirulence AT mackinnonm roleofimmunityinmosquitoinducedattenuationofmalariavirulence |