Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

Thymic cysts originate from Foxn1 positive thymic medullary epithelium.

Thymic epithelial cells (TECs), derived from polarized two-dimensional (2D) oriented endodermal cells, are distinguished from other epithelial cells by their unique three-dimensional (3D) phenotype. However, some polarized epithelial cells remain present in the normal thymus, forming thymic cysts at...

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Bibliografiske detaljer
Main Authors:	Vroegindeweij, E, Crobach, S, Itoi, M, Satoh, R, Zuklys, S, Happe, C, Germeraad, W, Cornelissen, J, Cupedo, T, Holländer, G, Kawamoto, H, van Ewijk, W
Format:	Journal article
Sprog:	English
Udgivet:	2010

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af: Jenkinson, SR, et al.
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