Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis.
Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia t...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1826296276031897600 |
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| author | Chierakul, W de Fost, M Suputtamongkol, Y Limpaiboon, R Dondorp, A White, N van der Poll, T |
| author_facet | Chierakul, W de Fost, M Suputtamongkol, Y Limpaiboon, R Dondorp, A White, N van der Poll, T |
| author_sort | Chierakul, W |
| collection | OXFORD |
| description | Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. |
| first_indexed | 2024-03-07T04:13:50Z |
| format | Journal article |
| id | oxford-uuid:c8b8a82f-f68e-4f3d-a4a1-660fc0201769 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:13:50Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:c8b8a82f-f68e-4f3d-a4a1-660fc02017692022-03-27T06:54:14ZDifferential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:c8b8a82f-f68e-4f3d-a4a1-660fc0201769EnglishSymplectic Elements at Oxford2004Chierakul, Wde Fost, MSuputtamongkol, YLimpaiboon, RDondorp, AWhite, Nvan der Poll, TInterferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. |
| spellingShingle | Chierakul, W de Fost, M Suputtamongkol, Y Limpaiboon, R Dondorp, A White, N van der Poll, T Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. |
| title | Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. |
| title_full | Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. |
| title_fullStr | Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. |
| title_full_unstemmed | Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. |
| title_short | Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis. |
| title_sort | differential expression of interferon gamma and interferon gamma inducing cytokines in thai patients with scrub typhus or leptospirosis |
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